Varaico: Literature-Extracted Genetic Variants

Gene:PTEN
Variant:p.E18A
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PTEN

NM_000314.8:p.E18A

Associated Papers

Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9-mediated genome engineering in HAP1 cells mimicking cancer profiles.

Geng K et al.

Life Science Alliance, 2024

37984988 (PubMed )
Supplement: LSA-2023-02128_TableS13.xlsx › Table_S13

Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer.

Serebriiskii IG et al.

Npj Genomic Medicine, 2023

38001126 (PubMed )
Supplement: 41525_2023_384_MOESM1_ESM.xlsx › Table_S8

A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity.

Gil A et al.

Plos One, 2015

In vivo functional analysis of the counterbalance of hyperactive phosphatidylinositol 3-kinase p110 catalytic oncoproteins by the tumor suppressor PTEN.

Andrés-Pons A et al.

Cancer Research, 2007

A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth.

Denning G et al.

Oncogene, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."