Associated Papers
Cancer and disease profiles for PTEN pathogenic variants in Japanese population.
Kanazashi Y et al.
Journal of Human Genetics, 2025
Pembrolizumab efficacy in a tumor mutation burden-high glioblastoma patient: A case study and implications for precision oncology.
Nishiyama A et al.
Cancer Science, 2025
Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer.
Serebriiskii IG et al.
Npj Genomic Medicine, 2023
Classification of PTEN missense VUS through exascale simulations.
Sinha S et al.
Briefings in Bioinformatics, 2023
Detecting macroevolutionary genotype-phenotype associations using error-corrected rates of protein convergence.
Fukushima K et al.
Nature Ecology & Evolution, 2023
Molecular dynamic simulation and functional analysis of pathogenic PTEN mutations in glioblastoma.
Cetintas VB et al.
Journal of Biomolecular Structure & Dynamics, 2023
Tracking tumor evolution during the first-line treatment in brain glioma via serial profiling of cell-free tumor DNA from tumor in situ fluid.
Sheng Z et al.
Frontiers in Oncology, 2023
Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers.
Serebriiskii IG et al.
Nature Communications, 2022
Mechanism of activation and the rewired network: New drug design concepts.
Nussinov R et al.
Medicinal Research Reviews, 2022
Integrated genomics point to immune vulnerabilities in pleural mesothelioma.
Nastase A et al.
Scientific Reports, 2021
Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition.
Nussinov R et al.
Molecular Cancer Research : Mcr, 2021
Analyzing aggregation propensities of clinically relevant PTEN mutants: a new culprit in pathogenesis of cancer and other PTENopathies.
Palumbo E et al.
Journal of Biomolecular Structure & Dynamics, 2020
Structural Mechanisms of PTEN Regulation.
Masson GR et al.
Cold Spring Harbor Perspectives in Medicine, 2020
The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.
Hasle N et al.
Cold Spring Harbor Perspectives in Medicine, 2019
Characterization of potential driver mutations involved in human breast cancer by computational approaches.
Rajendran BK et al.
Oncotarget, 2017
An extensive molecular cytogenetic characterization in high-risk chronic lymphocytic leukemia identifies karyotype aberrations and TP53 disruption as predictors of outcome and chemorefractoriness.
Rigolin GM et al.
Oncotarget, 2017
Extensive next-generation sequencing analysis in chronic lymphocytic leukemia at diagnosis: clinical and biological correlations.
Rigolin GM et al.
Journal of Hematology & Oncology, 2016
Next-generation sequencing identifies high frequency of mutations in potentially clinically actionable genes in sebaceous carcinoma.
Tetzlaff MT et al.
The Journal of Pathology, 2016
Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins.
Verrastro I et al.
Free Radical Biology & Medicine, 2016
A new class of cancer-associated PTEN mutations defined by membrane translocation defects.
Nguyen HN et al.
Oncogene, 2015
Engineering PTEN function: membrane association and activity.
Yang JM et al.
Methods (san Diego, Calif.), 2015
Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy.
Tan CL et al.
Cell Cycle (georgetown, Tex.), 2015
A new insight into structural and functional impact of single-nucleotide polymorphisms in PTEN gene.
George Priya Doss C et al.
Cell Biochemistry and Biophysics, 2013
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
Coffill CR et al.
Embo Reports, 2012
The functions and regulation of the PTEN tumour suppressor.
Song MS et al.
Nature Reviews. Molecular Cell Biology, 2012
Protein interactions of phosphatase and tensin homologue (PTEN) and its cancer-associated G20E mutant compared by using stable isotope labeling by amino acids in cell culture-based parallel affinity purification.
Gunaratne J et al.
The Journal of Biological Chemistry, 2011
A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth.
Denning G et al.
Oncogene, 2007
Genetic screening for hereditary diffuse gastric cancer.
Oliveira C et al.
Expert Review of Molecular Diagnostics, 2003