Associated Papers
Recombination between fragile regions associated with chromosomal rearrangements in glioblastoma can be mediated by RAGs.
Paranjape A et al.
Iscience, 2025
PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer.
Liu F et al.
Oncogene, 2025
PTEN loss in glioma cell lines leads to increased extracellular vesicle biogenesis and PD-L1 cargo in a PI3K-dependent manner.
Sanchez JC et al.
The Journal of Biological Chemistry, 2025
Anticancer effect of the oncolytic Newcastle disease virus harboring the PTEN gene on glioblastoma.
Kim S et al.
Oncology Letters, 2025
IDH1 and ATRX mutations synergistically modulate cell proliferation and ferroptosis in glioblastoma cells.
Liu S et al.
American Journal of Cancer Research, 2025
Pleiotropic tumor suppressive functions of PTEN missense mutations during gliomagenesis.
Jun HJ et al.
Iscience, 2024
PTEN loss in glioma cell lines leads to increased extracellular vesicles biogenesis and PD-L1 cargo in a PI3K-dependent manner.
Sanchez JC et al.
Biorxiv : the Preprint Server for Biology, 2024
STING activation increases the efficiency of temozolomide in PTEN harbouring glioblastoma cells.
Yildirim Z et al.
Turkish Journal of Medical Sciences, 2024
Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer.
Serebriiskii IG et al.
Npj Genomic Medicine, 2023
Nuclear transport surveillance of p53 by nuclear pores in glioblastoma.
Ikliptikawati DK et al.
Cell Reports, 2023
AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells.
Cahuzac KM et al.
Cell Reports, 2023
BLM helicase overexpressed in human gliomas contributes to diverse responses of human glioma cells to chemotherapy.
Wojnicki K et al.
Cell Death Discovery, 2023
PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors.
Ferdosi SR et al.
Neuro-oncology, 2022
Smurf1 Suppression Enhances Temozolomide Chemosensitivity in Glioblastoma by Facilitating PTEN Nuclear Translocation.
Dong L et al.
Cells, 2022
The phosphatase and tensin homolog gene inserted between NP and P gene of recombinant New castle disease virus oncolytic effect test to glioblastoma cell and xenograft mouse model.
Jang SH et al.
Virology Journal, 2022
Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2.
Enrico TP et al.
Elife, 2021
Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers.
Matreyek KA et al.
Genome Medicine, 2021
Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage.
Amen AM et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021
Heat Shock Protein Inhibitor 17-Allyamino-17-Demethoxygeldanamycin, a Potent Inductor of Apoptosis in Human Glioma Tumor Cell Lines, Is a Weak Substrate for ABCB1 and ABCG2 Transporters.
Pastvova N et al.
Pharmaceuticals (basel, Switzerland), 2021
Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways in Human Glioblastoma Cells Independently of Deficiency in TP53 or PTEN Tumor Suppressors.
Ellert-Miklaszewska A et al.
Cancers, 2021
PARP‑1 inhibition sensitizes temozolomide‑treated glioblastoma cell lines and decreases drug resistance independent of MGMT activity and PTEN proficiency.
Montaldi AP et al.
Oncology Reports, 2020
BRAF status modulates Interelukin-8 expression through a CHOP-dependent mechanism in colorectal cancer.
Conciatori F et al.
Communications Biology, 2020
Targeting the Synthetic Vulnerability of PTEN-Deficient Glioblastoma Cells with MCL1 Inhibitors.
Chen C et al.
Molecular Cancer Therapeutics, 2020
Analyzing aggregation propensities of clinically relevant PTEN mutants: a new culprit in pathogenesis of cancer and other PTENopathies.
Palumbo E et al.
Journal of Biomolecular Structure & Dynamics, 2020
OCT4B Isoform Promotes Anchorage-Independent Growth of Glioblastoma Cells.
Choi SH et al.
Molecules and Cells, 2019
Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients.
Koyama T et al.
Bmc Cancer, 2019
ARL4C stabilized by AKT/mTOR pathway promotes the invasion of PTEN-deficient primary human glioblastoma.
Chen Q et al.
The Journal of Pathology, 2019
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation.
Li AG et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018
Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma.
Wang Y et al.
Cancer Letters, 2018
65 YEARS OF THE DOUBLE HELIX: The advancements of gene editing and potential application to hereditary cancer.
Tan ZY et al.
Endocrine-related Cancer, 2018
DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.
Caron A et al.
Physiological Reviews, 2018
Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status.
Comelli M et al.
Journal of Bioenergetics and Biomembranes, 2018
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.
Gu Y et al.
Molecular Cell, 2017
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.
Kuchay S et al.
Nature, 2017
PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3.
Benitez JA et al.
Nature Communications, 2017
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.
Milella M et al.
Scientific Reports, 2017
Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.
Kang YJ et al.
Nature Communications, 2017
The E3 ubiquitin ligase CHIP/miR-92b/PTEN regulatory network contributes to tumorigenesis of glioblastoma.
Xu T et al.
American Journal of Cancer Research, 2017
Correction of PTEN mutations in glioblastoma cell lines via AAV-mediated gene editing.
Hill VK et al.
Plos One, 2017
Genomic Analysis of Uterine Lavage Fluid Detects Early Endometrial Cancers and Reveals a Prevalent Landscape of Driver Mutations in Women without Histopathologic Evidence of Cancer: A Prospective Cross-Sectional Study.
Nair N et al.
Plos Medicine, 2016
PTEN negatively regulates mTORC2 formation and signaling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of an mTORC1/2 inhibitor.
Bhattacharya K et al.
Oncogenesis, 2016