Associated Papers
PTEN protein phosphatase activity regulates metastasis by targeting PKCδ.
Yu Y et al.
Iscience, 2025
Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer.
Serebriiskii IG et al.
Npj Genomic Medicine, 2023
PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6.
Yu Y et al.
Iscience, 2023
PTEN is required for the migration and invasion of Ras-transformed MDCK cells.
Yan L et al.
Febs Letters, 2021
Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma.
Wang Y et al.
Cancer Letters, 2018
Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays, and macrocephaly.
Wong CW et al.
Autism Research : Official Journal of the International Society for Autism Research, 2018
AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma.
Zuo Q et al.
Oncogene, 2018
Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer.
Alioui A et al.
Nature Communications, 2017
Association between TLR4 and PTEN Involved in LPS-TLR4 Signaling Response.
Yin H et al.
Biomed Research International, 2016
PTEN Inhibits Cell Proliferation, Promotes Cell Apoptosis, and Induces Cell Cycle Arrest via Downregulating the PI3K/AKT/hTERT Pathway in Lung Adenocarcinoma A549 Cells.
Lu XX et al.
Biomed Research International, 2016
The PTEN/NRF2 axis promotes human carcinogenesis.
Rojo AI et al.
Antioxidants & Redox Signaling, 2014
The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation.
Ahmed SF et al.
The Journal of Biological Chemistry, 2012
Regulation of nuclear TDP-43 by NR2A-containing NMDA receptors and PTEN.
Zheng M et al.
Journal of Cell Science, 2012
Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line.
Singh G et al.
Bmc Cancer, 2011
NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration.
Kwak YD et al.
Molecular Neurodegeneration, 2010
Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN.
Chia JY et al.
Biochimica Et Biophysica Acta, 2010
Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.
Furgeson SB et al.
Cardiovascular Research, 2010
Reversal of the malignant phenotype of ovarian cancer A2780 cells through transfection with wild-type PTEN gene.
Wu H et al.
Cancer Letters, 2008
PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations.
Li Y et al.
Cancer Research, 2008
PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.
Xiao Y et al.
Cellular Signalling, 2007
Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression.
Cai XM et al.
International Journal of Cancer, 2005
Regulation of c-Met-dependent gene expression by PTEN.
Abounader R et al.
Oncogene, 2004
[PTEN induces apoptosis and up-regulates p53 expression in HepG2 cells].
Yang ZF et al.
Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology, 2004
Human cancer, PTEN and the PI-3 kinase pathway.
Parsons R
Seminars in Cell & Developmental Biology, 2004
PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility.
Sugatani T et al.
The Journal of Biological Chemistry, 2003
The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness.
Kotelevets L et al.
The Journal of Cell Biology, 2001
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway.
Tamura M et al.
The Journal of Biological Chemistry, 1999
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways.
Gu J et al.
The Journal of Cell Biology, 1998
Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN.
Church JE et al.
Vascular Pharmacology, 0