Varaico: Literature-Extracted Genetic Variants

Gene:PTEN
Variant:p.Y174F
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PTEN

NM_000314.8:p.Y174F

Associated Papers

PTEN is both an activator and a substrate of chaperone-mediated autophagy.

Zhang KK et al.

The Journal of Cell Biology, 2023

vaRHC: an R package for semi-automation of variant classification in hereditary cancer genes according to ACMG/AMP and gene-specific ClinGen guidelines.

Munté E et al.

Bioinformatics (oxford, England), 2023

36916756 (PubMed )
Supplement: btad128_supplementary_data.zip › btad128_Supplementary_Data › Supplementary_tables10022023.xlsx › ST15-PS1_PM5_hypothethical_vars

Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor.

Liu J et al.

Oncogene, 2014

WWP2 is an E3 ubiquitin ligase for PTEN.

Maddika S et al.

Nature Cell Biology, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."