Varaico: Literature-Extracted Genetic Variants

Gene:PTEN
Variant:p.E288fs
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PTEN

NM_000314.8:p.E288fs

Associated Papers

Common gene mutations in 103 authenticated colorectal cancer cell lines.

Kranjec C et al.

Oncogenesis, 2026

41593049 (PubMed )
Supplement: 41389_2026_599_MOESM2_ESM.xlsx › Supplementary_Table_9

Somatic mutations in Middle East and North Africa breast cancer patients: a systematic review.

Abujamous L et al.

The Oncologist, 2025

40665690 (PubMed )
Supplement: oyaf205_supplementary_data.zip › SupplementaryTable3.xlsx › SupplementaryTable3

Targeted next-generation sequencing of 491 lung cancers in clinical practice: Implications for future detection strategy and targeted therapy.

Liu XD et al.

Heliyon, 2024

38496837 (PubMed )
Supplement: mmc1.xlsx › Sheet1

Landscape of potentially targetable receptor tyrosine kinase fusions in diverse cancers by DNA-based profiling.

Wang T et al.

Npj Precision Oncology, 2022

36369474 (PubMed )
Supplement: 41698_2022_325_MOESM1_ESM.pdf

Mosaicism in Tumor Suppressor Gene Syndromes: Prevalence, Diagnostic Strategies, and Transmission Risk.

Chen JL et al.

Annual Review of Genomics and Human Genetics, 2022

36044908 (PubMed )
Supplement: gg23-giannikou_suptable1.xlsx › PTEN

GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers.

Bianco G et al.

Communications Biology, 2022

35440675 (PubMed )
Supplement: 42003_2022_3296_MOESM4_ESM.xlsx › S1

Targeted next generation sequencing identifies somatic mutations in a cohort of Egyptian breast cancer patients.

Nassar A et al.

Journal of Advanced Research, 2020

Identification of Circulating Genomic and Metabolic Biomarkers in Intrahepatic Cholangiocarcinoma.

Winter H et al.

Cancers, 2019

31795195 (PubMed )
Supplement: cancers-11-01895-s001.zip › ICC_ctDNA_Cancers_Supplementary_Table_5._50_cancer_gene_panel_information.xlsx › cms_106003

Identification of novel mutations in FFPE lung adenocarcinomas using DEPArray sorting technology and next-generation sequencing.

Lee JW et al.

Journal of Applied Genetics, 2018

29525983 (PubMed )
Supplement: 13353_2018_439_MOESM3_ESM.xlsx › Table_S2B

Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Chen F et al.

Nature Communications, 2017

28775315 (PubMed )
Supplement: 41467_2017_289_MOESM7_ESM.xlsx › mutation_data

Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing.

Jauhri M et al.

Medical Oncology (northwood, London, England), 2016

Paclitaxel is necessary for improved survival in epithelial ovarian cancers with homologous recombination gene mutations.

Jean S et al.

Oncotarget, 2016

27191893 (PubMed )
Supplement: oncotarget-07-48577-s002.xlsx › Sheet1

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial.

Jovelet C et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2016

26758560 (PubMed )
Supplement: 10780432ccr152470-sup-156650_1_supp_3254814_ny79rd.xlsx › AF_T-P

PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: two hits on the gene?

Hühns M et al.

Oncology Reports, 2014

Inferring primary tumor sites from mutation spectra: a meta-analysis of histology-specific aberrations in cancer-derived cell lines.

Dietlein F et al.

Human Molecular Genetics, 2014

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.

Vizeacoumar FJ et al.

Molecular Systems Biology, 2013

24104479 (PubMed )
Supplement: msb201354-s13.xlsx › PTEN_PIK3CA_status_of_cell-line

PI3K pathway dependencies in endometrioid endometrial cancer cell lines.

Weigelt B et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2013

Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells.

Konecny GE et al.

Molecular Cancer Therapeutics, 2013

Comprehensive molecular portraits of human breast tumours.

Unknown Author

Nature, 2012

23000897 (PubMed )
Supplement: NIHMS393293-supplement-4.xls › Sheet_1
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."