Associated Papers
Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome.
Tibarewal P et al.
Disease Models & Mechanisms, 2026
Cell-free DNA fragmentomics and second malignant neoplasm risk in patients with PTEN hamartoma tumor syndrome.
Liu D et al.
Cell Reports. Medicine, 2024
The E3 ubiquitin ligase CHIP drives monoubiquitylation-mediated nuclear import of the tumor suppressor PTEN.
Chakraborty S et al.
Journal of Cell Science, 2023
PTEN deficiency facilitates gemcitabine efficacy in cancer by modulating the phosphorylation of PP2Ac and DCK.
Jiang TY et al.
Science Translational Medicine, 2023
PTEN Deficiency Facilitates Exosome Secretion and Metastasis in Cholangiocarcinoma by Impairing TFEB-mediated Lysosome Biogenesis.
Jiang TY et al.
Gastroenterology, 2023
Nuclear PTEN's Functions in Suppressing Tumorigenesis: Implications for Rare Cancers.
Langdon CG
Biomolecules, 2023
Molecular dynamic simulation and functional analysis of pathogenic PTEN mutations in glioblastoma.
Cetintas VB et al.
Journal of Biomolecular Structure & Dynamics, 2023
Novel anti-PTEN C2 domain monoclonal antibodies to analyse the expression and function of PTEN isoform variants.
Torices L et al.
Plos One, 2023
Smurf1 Suppression Enhances Temozolomide Chemosensitivity in Glioblastoma by Facilitating PTEN Nuclear Translocation.
Dong L et al.
Cells, 2022
Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.
G V et al.
Frontiers in Genetics, 2022
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Dai C et al.
Cell Death and Differentiation, 2021
Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma.
Choi SW et al.
Cell Death & Disease, 2021
Autism-associated PTEN missense mutation leads to enhanced nuclear localization and neurite outgrowth in an induced pluripotent stem cell line.
Wong CW et al.
The Febs Journal, 2020
Posttranslational Regulation and Conformational Plasticity of PTEN.
Kotelevets L et al.
Cold Spring Harbor Perspectives in Medicine, 2020
Analyzing aggregation propensities of clinically relevant PTEN mutants: a new culprit in pathogenesis of cancer and other PTENopathies.
Palumbo E et al.
Journal of Biomolecular Structure & Dynamics, 2020
PTEN in Hereditary and Sporadic Cancer.
Ngeow J et al.
Cold Spring Harbor Perspectives in Medicine, 2020
Role of Ubiquitination in PTEN Cellular Homeostasis and Its Implications in GB Drug Resistance.
Xia Q et al.
Frontiers in Oncology, 2020
The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.
Hasle N et al.
Cold Spring Harbor Perspectives in Medicine, 2019
Systematic analysis of the intersection of disease mutations with protein modifications.
Simpson CM et al.
Bmc Medical Genomics, 2019
PTEN-opathies: from biological insights to evidence-based precision medicine.
Yehia L et al.
The Journal of Clinical Investigation, 2019
Disruption of protein function by pathogenic mutations: common and uncommon mechanisms 1.
Taipale M
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 2019
Nuclear PTEN Localization Contributes to DNA Damage Response in Endometrial Adenocarcinoma and Could Have a Diagnostic Benefit for Therapeutic Management of the Disease.
Mukherjee A et al.
Molecular Cancer Therapeutics, 2018
Nuclear Excluded Autism-Associated Phosphatase and Tensin Homolog Mutations Dysregulate Neuronal Growth.
Fricano-Kugler CJ et al.
Biological Psychiatry, 2018
Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays, and macrocephaly.
Wong CW et al.
Autism Research : Official Journal of the International Society for Autism Research, 2018
65 YEARS OF THE DOUBLE HELIX: One gene, many endocrine and metabolic syndromes: PTEN-opathies and precision medicine.
Yehia L et al.
Endocrine-related Cancer, 2018
Multiplex assessment of protein variant abundance by massively parallel sequencing.
Matreyek KA et al.
Nature Genetics, 2018
A Saturation Mutagenesis Approach to Understanding PTEN Lipid Phosphatase Activity and Genotype-Phenotype Relationships.
Mighell TL et al.
American Journal of Human Genetics, 2018
PTEN: Tumor Suppressor and Metabolic Regulator.
Chen CY et al.
Frontiers in Endocrinology, 2018
The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.
Chen M et al.
The Journal of Cell Biology, 2017
DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue.
Wu R et al.
Cell Discovery, 2017
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis.
He J et al.
Nature Communications, 2016
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Li S et al.
Nature Immunology, 2016
Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder.
Tilot AK et al.
Molecular Psychiatry, 2016
A systematic screening to identify de novo mutations causing sporadic early-onset Parkinson's disease.
Kun-Rodrigues C et al.
Human Molecular Genetics, 2015
Molecular functions of NEDD4 E3 ubiquitin ligases in cancer.
Zou X et al.
Biochimica Et Biophysica Acta, 2015
Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN.
Nguyen HN et al.
Scientific Reports, 2015
Protein monoubiquitylation: targets and diverse functions.
Nakagawa T et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2015
Analysis of PTEN ubiquitylation and SUMOylation using molecular traps.
Lang V et al.
Methods (san Diego, Calif.), 2015
Study of PTEN subcellular localization.
Bononi A et al.
Methods (san Diego, Calif.), 2015
Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity.
Howitt J et al.
Journal of Molecular Cell Biology, 2015
Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes.
Spinelli L et al.
Journal of Medical Genetics, 2015
A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.
Lima-Fernandes E et al.
Nature Communications, 2014
Rab5 and Ndfip1 are involved in Pten ubiquitination and nuclear trafficking.
Li Y et al.
Traffic (copenhagen, Denmark), 2014