Associated Papers
The E3 ubiquitin ligase CHIP drives monoubiquitylation-mediated nuclear import of the tumor suppressor PTEN.
Chakraborty S et al.
Journal of Cell Science, 2023
Novel anti-PTEN C2 domain monoclonal antibodies to analyse the expression and function of PTEN isoform variants.
Torices L et al.
Plos One, 2023
TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer.
He YM et al.
Acta Pharmacologica Sinica, 2022
Non-canonical function of nuclear PTEN and its implication on tumorigenesis.
Misra S et al.
Dna Repair, 2021
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Dai C et al.
Cell Death and Differentiation, 2021
The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma.
Kato T et al.
Iscience, 2020
33083717 (PubMed )
Supplement: mmc1.pdf
PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.
Zhang J et al.
Cancer Discovery, 2019
Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis.
Sisti F et al.
Science Signaling, 2018
Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization.
Yang JM et al.
Oncogene, 2017
28263967 (PubMed )
Supplement: onc2016493x1.pdf
Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.
Gupta A et al.
The Journal of Biological Chemistry, 2016
Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency.
Kovac M et al.
Nature Communications, 2015
26632267 (PubMed )
Supplement: ncomms9940-s1.pdf
PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis.
Lee MS et al.
Nature Communications, 2015
E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.
Guo H et al.
Cell Reports, 2012
PTEN acetylation modulates its interaction with PDZ domain.
Ikenoue T et al.
Cancer Research, 2008
Ubiquitination regulates PTEN nuclear import and tumor suppression.
Trotman LC et al.
Cell, 2007
The Nuclear Face of PTEN: Implications in Cancer Prognosis and Targeted Therapy.
Ghosh MK et al.
Biofactors (oxford, England), 0
Select a paper to view details