Associated Papers
USP10/GSK3β-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer.
Kumari N et al.
The Journal of Clinical Investigation, 2025
Molecular dynamic simulation and functional analysis of pathogenic PTEN mutations in glioblastoma.
Cetintas VB et al.
Journal of Biomolecular Structure & Dynamics, 2023
The impact of phosphorylated PTEN at threonine 366 on cortical connectivity and behaviour.
Ledderose JMT et al.
Brain : a Journal of Neurology, 2022
Loss of PTEN phosphorylation via single point mutation alters cortical connectivity and behaviour.
Binder M et al.
Brain : a Journal of Neurology, 2022
Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers.
Serebriiskii IG et al.
Nature Communications, 2022
Palmitic acid negatively regulates tumor suppressor PTEN through T366 phosphorylation and protein degradation.
Bai D et al.
Cancer Letters, 2021
The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma.
Kato T et al.
Iscience, 2020
The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.
Hasle N et al.
Cold Spring Harbor Perspectives in Medicine, 2019
Multiplex assessment of protein variant abundance by massively parallel sequencing.
Matreyek KA et al.
Nature Genetics, 2018
Growth of B Cell Receptor Microclusters Is Regulated by PIP2 and PIP3 Equilibrium and Dock2 Recruitment and Activation.
Wang J et al.
Cell Reports, 2017
Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization.
Yang JM et al.
Oncogene, 2017
The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.
Masson GR et al.
The Biochemical Journal, 2016
Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.
Stumpf M et al.
Plos One, 2016
Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium.
Nguyen HN et al.
Oncogene, 2014
Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin.
Choi BH et al.
The Journal of Biological Chemistry, 2014
Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle.
Choi BH et al.
The Journal of Biological Chemistry, 2014
Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.
Berglund FM et al.
Oncogene, 2013
Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis.
Bolduc D et al.
Elife, 2013
PTEN regulation by the Akt/GSK-3β axis during RANKL signaling.
Jang HD et al.
Bone, 2013
PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity.
Tibarewal P et al.
Science Signaling, 2012
Regulation of PTEN stability and activity by Plk3.
Xu D et al.
The Journal of Biological Chemistry, 2010
Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels.
Ning K et al.
The Journal of Biological Chemistry, 2009
PTEN is destabilized by phosphorylation on Thr366.
Maccario H et al.
The Biochemical Journal, 2007
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta.
Al-Khouri AM et al.
The Journal of Biological Chemistry, 2005
PTEN: a novel anti-oncogenic function independent of phosphatase activity.
Okumura K et al.
Cell Cycle (georgetown, Tex.), 2005
Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor.
Okumura K et al.
Proceedings of the National Academy of Sciences of the United States of America, 2005