Associated Papers
USP10/GSK3β-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer.
Kumari N et al.
The Journal of Clinical Investigation, 2025
Elucidating PTEN conformational dynamics and phosphatase regulation via integrative modeling and mutation prediction.
Dawson JE et al.
Structure (london, England : 1993), 2025
NHEJ is promoted by the phosphorylation and phosphatase activity of PTEN via regulation of DNA-PKcs.
Chowdhury SG et al.
Biochimica Et Biophysica Acta. Molecular Cell Research, 2024
Sumoylation and phosphorylation of PTEN boosts and curtails autophagy respectively by influencing cell membrane localisation.
De D et al.
Experimental Cell Research, 2024
Hyperphosphorylated PTEN exerts oncogenic properties.
van Ree JH et al.
Nature Communications, 2023
Phospho PTEN mediated dephosphorylation of mitotic kinase PLK1 and Aurora Kinase A prevents aneuploidy and preserves genomic stability.
Ghosh G et al.
Medical Oncology (northwood, London, England), 2023
Targeting PTEN Regulation by Post Translational Modifications.
González-García A et al.
Cancers, 2022
Structural and Dynamic Effects of PTEN C-Terminal Tail Phosphorylation.
Smith IN et al.
Journal of Chemical Information and Modeling, 2022
Pten Regulates Cardiomyocyte Differentiation by Modulating Non-CG Methylation via Dnmt3.
Wang W et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2021
The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma.
Kato T et al.
Iscience, 2020
YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.
Zhao L et al.
Molecular and Cellular Probes, 2020
Circulating tumour DNA in metastatic breast cancer to guide clinical trial enrolment and precision oncology: A cohort study.
Zivanovic Bujak A et al.
Plos Medicine, 2020
Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells.
Wang W et al.
Cell Death & Disease, 2020
The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.
Hasle N et al.
Cold Spring Harbor Perspectives in Medicine, 2019
PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex.
Javadi A et al.
Elife, 2017
Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.
Kang YJ et al.
Nature Communications, 2017
Exogenous induction of unphosphorylated PTEN reduces TGFβ-induced extracellular matrix expressions in lung fibroblasts.
Kimura M et al.
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society, 2017
Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.
Gupta A et al.
The Journal of Biological Chemistry, 2016
The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.
Masson GR et al.
The Biochemical Journal, 2016
Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer.
Kim SJ et al.
Oncogene, 2016
Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers.
Kohnoh T et al.
Cancer Cell International, 2016
Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis.
Stumpf M et al.
Plos One, 2016
Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells.
Kusunose M et al.
Cancer Science, 2015
Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach.
Malaney P et al.
Methods (san Diego, Calif.), 2015
Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis.
Ahmed SF et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy, 2015
BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation.
Morotti A et al.
Cell Cycle (georgetown, Tex.), 2015
Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium.
Nguyen HN et al.
Oncogene, 2014
Phosphorylation of PTEN at STT motif is associated with DNA damage response.
Misra S et al.
Mutation Research, 2014
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.
Li Z et al.
Molecular and Cellular Biology, 2014
Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein.
Maehama T et al.
The Journal of Biological Chemistry, 2014
A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.
Lima-Fernandes E et al.
Nature Communications, 2014
Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin.
Choi BH et al.
The Journal of Biological Chemistry, 2014
Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle.
Choi BH et al.
The Journal of Biological Chemistry, 2014
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.
Papa A et al.
Cell, 2014
Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.
Nakahata S et al.
Nature Communications, 2014
TOPK and PTEN participate in CHFR mediated mitotic checkpoint.
Shinde SR et al.
Cellular Signalling, 2013
Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.
Patel R et al.
The Journal of Clinical Investigation, 2013
Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.
Beckham TH et al.
Plos One, 2013
Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells.
Aoyama D et al.
Plos One, 2013
Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR.
Cordier F et al.
Journal of the American Chemical Society, 2012
Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus.
Andrés-Pons A et al.
Cellular Signalling, 2012
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia.
Howitt J et al.
The Journal of Cell Biology, 2012
A mutant form of PTEN linked to autism.
Redfern RE et al.
Protein Science : a Publication of the Protein Society, 2010
Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons.
Oinuma I et al.
The Journal of Biological Chemistry, 2010
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.
Maccario H et al.
The Journal of Biological Chemistry, 2010
PTEN-Associated Complexes: An Overview.
Mosessian S et al.
Current Topics in Biochemical Research, 2010