Associated Papers
USP10/GSK3β-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer.
Kumari N et al.
The Journal of Clinical Investigation, 2025
Elucidating PTEN conformational dynamics and phosphatase regulation via integrative modeling and mutation prediction.
Dawson JE et al.
Structure (london, England : 1993), 2025
NHEJ is promoted by the phosphorylation and phosphatase activity of PTEN via regulation of DNA-PKcs.
Chowdhury SG et al.
Biochimica Et Biophysica Acta. Molecular Cell Research, 2024
Sumoylation and phosphorylation of PTEN boosts and curtails autophagy respectively by influencing cell membrane localisation.
De D et al.
Experimental Cell Research, 2024
Hyperphosphorylated PTEN exerts oncogenic properties.
van Ree JH et al.
Nature Communications, 2023
Phospho PTEN mediated dephosphorylation of mitotic kinase PLK1 and Aurora Kinase A prevents aneuploidy and preserves genomic stability.
Ghosh G et al.
Medical Oncology (northwood, London, England), 2023
Structural or functional defects of PTEN in urothelial cells lacking P53 drive basal/squamous-subtype muscle-invasive bladder cancer.
He F et al.
Cancer Letters, 2022
Structural and Dynamic Effects of PTEN C-Terminal Tail Phosphorylation.
Smith IN et al.
Journal of Chemical Information and Modeling, 2022
The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma.
Kato T et al.
Iscience, 2020
The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.
Hasle N et al.
Cold Spring Harbor Perspectives in Medicine, 2019
Multiplex assessment of protein variant abundance by massively parallel sequencing.
Matreyek KA et al.
Nature Genetics, 2018
PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex.
Javadi A et al.
Elife, 2017
Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.
Kang YJ et al.
Nature Communications, 2017
Exogenous induction of unphosphorylated PTEN reduces TGFβ-induced extracellular matrix expressions in lung fibroblasts.
Kimura M et al.
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society, 2017
The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.
Masson GR et al.
The Biochemical Journal, 2016
Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers.
Kohnoh T et al.
Cancer Cell International, 2016
Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis.
Stumpf M et al.
Plos One, 2016
Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells.
Kusunose M et al.
Cancer Science, 2015
Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach.
Malaney P et al.
Methods (san Diego, Calif.), 2015
BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation.
Morotti A et al.
Cell Cycle (georgetown, Tex.), 2015
Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium.
Nguyen HN et al.
Oncogene, 2014
Phosphorylation of PTEN at STT motif is associated with DNA damage response.
Misra S et al.
Mutation Research, 2014
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.
Li Z et al.
Molecular and Cellular Biology, 2014
A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.
Lima-Fernandes E et al.
Nature Communications, 2014
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.
Papa A et al.
Cell, 2014
Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.
Nakahata S et al.
Nature Communications, 2014
Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.
Beckham TH et al.
Plos One, 2013
Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells.
Aoyama D et al.
Plos One, 2013
Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR.
Cordier F et al.
Journal of the American Chemical Society, 2012
Membrane association of the PTEN tumor suppressor: electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail.
Shenoy SS et al.
Journal of Structural Biology, 2012
Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus.
Andrés-Pons A et al.
Cellular Signalling, 2012
A mutant form of PTEN linked to autism.
Redfern RE et al.
Protein Science : a Publication of the Protein Society, 2010
PTEN-Associated Complexes: An Overview.
Mosessian S et al.
Current Topics in Biochemical Research, 2010
Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex.
Mosessian S et al.
The Journal of Biological Chemistry, 2009
Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration.
Heering J et al.
Experimental Cell Research, 2009
Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain.
Odriozola L et al.
The Journal of Biological Chemistry, 2007
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration.
Leslie NR et al.
Current Biology : Cb, 2007
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta.
Al-Khouri AM et al.
The Journal of Biological Chemistry, 2005
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
Mehenni H et al.
Human Molecular Genetics, 2005
RETRACTED: Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein.
Chung JH et al.
Cancer Research, 2005
Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions.
Torres J et al.
The Journal of Biological Chemistry, 2003
Direct identification of PTEN phosphorylation sites.
Miller SJ et al.
Febs Letters, 2002
Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation.
Birle D et al.
Journal of Immunology (baltimore, Md. : 1950), 2002
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation.
Torres J et al.
The Journal of Biological Chemistry, 2001
Both phosphorylation and phosphatase activity of PTEN are required to prevent replication fork progression during stress by inducing heterochromatin.
Misra S et al.
Mutation Research, 0