Varaico: Literature-Extracted Genetic Variants

Gene:PTEN
Variant:p.*404L
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PTEN

NM_000314.8:p.*404L

Associated Papers

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

Tibarewal P et al.

Advances in Biological Regulation, 2024

Clinical and analytical validation of FoundationOne Liquid CDx, a novel 324-Gene cfDNA-based comprehensive genomic profiling assay for cancers of solid tumor origin.

Woodhouse R et al.

Plos One, 2020

32976510 (PubMed )
Supplement: pone.0237802.s009.zip › Table_9_Accuracy_Short_Variant_Line_Data.xlsx › sheet_1

Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.

Berglund FM et al.

Oncogene, 2013

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity.

Tibarewal P et al.

Science Signaling, 2012

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.

Leslie NR et al.

The Biochemical Journal, 2001

Mutations of the human PTEN gene.

Bonneau D et al.

Human Mutation, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."