Varaico: Literature-Extracted Genetic Variants

Gene:PTGS2
Variant:p.V511A
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PTGS2

NM_000963.4:p.V511A

Associated Papers

Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review.

Gholamalizadeh M et al.

Frontiers in Oncology, 2022

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine.

Zhou Y et al.

Science Advances, 2021

34516913 (PubMed )
Supplement: sciadv.abi6856_tables_s1_to_s8.zip › sciadv.abi6856_Table_S4.xlsx › Sheet1

Association between COX2 -765G/C polymorphism and periodontitis in Chinese population: a meta-analysis.

Zhang ZS

Bmc Oral Health, 2018

Association of single nucleotide polymorphisms in MPO and COX genes with oral lichen planus.

Wu D et al.

International Journal of Immunogenetics, 2015

Association between cyclooxygenase-2 gene polymorphisms and risk of periodontitis: a meta-analysis involving 5653 individuals.

Jiang L et al.

Molecular Biology Reports, 2014

Cyclooxygenase-2 polymorphisms and susceptibility to colorectal cancer: a meta-analysis.

Wang J et al.

Yonsei Medical Journal, 2013

Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.

Tippin BL et al.

Prostaglandins & Other Lipid Mediators, 2012

Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors.

Liu W et al.

The Pharmacogenomics Journal, 2011

A new cyclo-oxygenase-2 gene variant in the Han Chinese population is associated with an increased risk of gastric carcinoma.

Li Y et al.

Molecular Diagnosis & Therapy, 2010

Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis.

Yu KD et al.

Breast Cancer Research and Treatment, 2010

Cyclooxygenase-2 Gly587Arg variant is associated with differential enzymatic activity and risk of esophageal squamous-cell carcinoma.

Zhao D et al.

Molecular Carcinogenesis, 2009

COX-2 polymorphisms -765G-->C and -1195A-->G and colorectal cancer risk.

Hoff JH et al.

World Journal of Gastroenterology, 2009

COX-2 polymorphisms and the risk for head and neck cancer in white patients.

Peters WH et al.

Head & Neck, 2009

Cyclooxygenase polymorphisms in gastric and colorectal carcinogenesis: are conclusive results available?

Pereira C et al.

European Journal of Gastroenterology & Hepatology, 2009

A review of gene-drug interactions for nonsteroidal anti-inflammatory drug use in preventing colorectal neoplasia.

Cross JT et al.

The Pharmacogenomics Journal, 2008

Cyclooxygenase-2 gene polymorphisms in an Australian population: association of the -1195G > A promoter polymorphism with mild asthma.

Shi J et al.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 2008

Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk: the Self Defense Forces Health Study.

Ueda N et al.

Cancer Science, 2008

COX-2 promoter region polymorphisms in multiple sclerosis: lack of association of -765G>C with disease risk.

Mazzola S et al.

International Journal of Immunogenetics, 2007

Polymorphisms in the genes involved in the arachidonic acid-pathway, fish consumption and the risk of colorectal cancer.

Siezen CL et al.

International Journal of Cancer, 2006

Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese population.

Liu F et al.

Gastroenterology, 2006

COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States).

Sansbury LB et al.

Cancer Causes & Control : Ccc, 2006

Cyclooxygenase 2 polymorphism (Val511Ala), nonsteroidal anti-inflammatory drug use and breast cancer in African American women.

Moorman PG et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2005

Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer.

Zhang X et al.

Gastroenterology, 2005

Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.

Goodman JE et al.

Carcinogenesis, 2004

Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer.

Cox DG et al.

British Journal of Cancer, 2004

An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology.

Zhu Y et al.

Cancer Research, 2004

Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase.

Choi JH et al.

Human Genetics, 2004

Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.

Lin HJ et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2002

Functional characterization of cyclooxygenase-2 polymorphisms.

Fritsche E et al.

The Journal of Pharmacology and Experimental Therapeutics, 2001

SNPs, protein structure, and disease.

Wang Z et al.

Human Mutation, 2001

Genetic association studies in digestive system malignancies.

Tsigris C et al.

Anticancer Research, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."