Varaico: Literature-Extracted Genetic Variants

Gene:PTK2B
Variant:p.Y402F
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PTK2B

NM_173176.3:p.Y402F

Associated Papers

Molecular basis and cellular effects of Janus-class-driven cytoplasmic PYK2 coacervates.

Colombo G et al.

Communications Biology, 2026

Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.

Li C et al.

Journal of Alzheimer's Disease : Jad, 2018

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.

Giralt A et al.

Nature Communications, 2017

Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase.

Suo L et al.

Journal of Molecular Cell Biology, 2012

Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene.

Maudsley S et al.

Molecular Endocrinology (baltimore, Md.), 2007

The tyrosine kinase pyk2 promotes migration and invasion of glioma cells.

Lipinski CA et al.

Neoplasia (new York, N.y.), 2005

Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2.

Butler B et al.

The Journal of Biological Chemistry, 2005

Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation.

Takahashi T et al.

The Journal of Biological Chemistry, 2003

Nuclear translocation of cell adhesion kinase beta/proline-rich tyrosine kinase 2.

Aoto H et al.

Cell Structure and Function, 2002

Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.

Ren XR et al.

The Journal of Cell Biology, 2001

Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1.

Kumar S et al.

The Journal of Biological Chemistry, 1999

Interactions between two cytoskeleton-associated tyrosine kinases: calcium-dependent tyrosine kinase and focal adhesion tyrosine kinase.

Li X et al.

The Journal of Biological Chemistry, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."