Varaico: Literature-Extracted Genetic Variants

Gene:PTK6
Variant:p.Y447F
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PTK6

NM_005975.4:p.Y447F

Associated Papers

Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer.

Liu C et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2021

PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.

Wozniak DJ et al.

Nature Communications, 2017

PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation.

Kang SA et al.

Biochemical and Biophysical Research Communications, 2013

Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo.

Miah S et al.

Oncogenesis, 2012

Identification of STAT3 as a specific substrate of breast tumor kinase.

Liu L et al.

Oncogene, 2006

An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.

Kim HIe et al.

The Journal of Biological Chemistry, 2005

Role of the Brk SH3 domain in substrate recognition.

Qiu H et al.

Oncogene, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."