Associated Papers
PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling.
Cen Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2026
Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes.
LeBleu G et al.
Journal of Cellular Physiology, 2026
Novel Function for Endothelial Protease-Activated Receptors in Modulating Insulin Receptor Activity With Implications for Diabetes.
Rajala R et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2025
PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling.
Cen Y et al.
Biorxiv : the Preprint Server for Biology, 2025
Structure of the phosphocysteine intermediate of the phosphatase of regenerating liver PTP4A1.
Mahbub L et al.
The Journal of Biological Chemistry, 2025
Endoplasmic reticulum-plasma membrane contact gradients direct cell migration.
Gong B et al.
Nature, 2024
Multiscale In Silico Study of the Mechanism of Activation of the RtcB Ligase by the PTP1B Phosphatase.
Mahdizadeh SJ et al.
Journal of Chemical Information and Modeling, 2024
Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte.
Hsu MF et al.
Biochimica Et Biophysica Acta. Molecular Cell Research, 2024
Identification of a Novel Hypoxia-induced Inflammatory Cell Death Pathway.
Bhardwaj A et al.
Biorxiv : the Preprint Server for Biology, 2023
Structure guided studies of the interaction between PTP1B and JAK.
Morris R et al.
Communications Biology, 2023
A PTP1B-Cdk3 Signaling Axis Promotes Cell Cycle Progression of Human Glioblastoma Cells through an Rb-E2F Dependent Pathway.
Villamar-Cruz O et al.
Molecular and Cellular Biology, 2023
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy.
Coulis G et al.
Science Signaling, 2022
Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14.
Rajala RVS et al.
Biomolecules, 2021
PTP1B up-regulates EGFR expression by dephosphorylating MYH9 at Y1408 to promote cell migration and invasion in esophageal squamous cell carcinoma.
Pan BQ et al.
Biochemical and Biophysical Research Communications, 2020
ER morphology and endo-lysosomal crosstalk: Functions and disease implications.
Lee CA et al.
Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids, 2020
A connection between reversible tyrosine phosphorylation and SNARE complex disassembly activity of N-ethylmaleimide-sensitive factor unveiled by the phosphomimetic mutant N-ethylmaleimide-sensitive factor-Y83E.
Ruete MC et al.
Molecular Human Reproduction, 2019
Spatial regulation of signaling by the coordinated action of the protein tyrosine kinases MET and FER.
Zhang J et al.
Cellular Signalling, 2018
Alternative translation initiation of Caveolin-2 desensitizes insulin signaling through dephosphorylation of insulin receptor by PTP1B and causes insulin resistance.
Kwon H et al.
Biochimica Et Biophysica Acta. Molecular Basis of Disease, 2018
Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.
Miller MB et al.
Acs Chemical Neuroscience, 2017
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Banh RS et al.
Nature Cell Biology, 2016
PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility.
González Wusener AE et al.
Biology Open, 2015
PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.
Krishnan N et al.
The Journal of Clinical Investigation, 2015
Subcellular Partitioning of Protein Tyrosine Phosphatase 1B to the Endoplasmic Reticulum and Mitochondria Depends Sensitively on the Composition of Its Tail Anchor.
Fueller J et al.
Plos One, 2015
Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma.
Walia V et al.
Human Mutation, 2014
Investigating the impact of Asp181 point mutations on interactions between PTP1B and phosphotyrosine substrate.
Liu M et al.
Scientific Reports, 2014
Bi-domain protein tyrosine phosphatases reveal an evolutionary adaptation to optimize signal transduction.
Ahuja LG et al.
Antioxidants & Redox Signaling, 2014
A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 protein insolubility and filament organization.
Snider NT et al.
The Journal of Biological Chemistry, 2013
Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B.
Bakke J et al.
Cell Communication and Signaling : Ccs, 2013
Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.
Bettaieb A et al.
Plos One, 2012
A new highly efficient substrate-trapping mutant of protein tyrosine phosphatase 1B (PTP1B) reveals full autoactivation of the insulin receptor precursor.
Boubekeur S et al.
The Journal of Biological Chemistry, 2011
The protein tyrosine phosphatase PTP1B is required for efficient delivery of N-cadherin to the cell surface.
Hernández MV et al.
Molecular Biology of the Cell, 2010
Crystal Structures of the histidine acid phosphatase from Francisella tularensis provide insight into substrate recognition.
Singh H et al.
Journal of Molecular Biology, 2009
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics.
Mertins P et al.
Molecular & Cellular Proteomics : Mcp, 2008
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
Dubois MJ et al.
Nature Medicine, 2006
ER-bound PTP1B is targeted to newly forming cell-matrix adhesions.
Hernández MV et al.
Journal of Cell Science, 2006
Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.
Zhang Z et al.
The Journal of Biological Chemistry, 2006
Visualization of SHP-1-target interaction.
Biskup C et al.
Journal of Cell Science, 2004
The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking.
Ragab A et al.
The Journal of Biological Chemistry, 2003
Functional characterization and crystal structure of the C215D mutant of protein-tyrosine phosphatase-1B.
Romsicki Y et al.
The Journal of Biological Chemistry, 2003
A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell antigen 512 (IA-2) and phogrin (IA-2beta).
Drake PG et al.
The Biochemical Journal, 2003
Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant.
Xie L et al.
Biochemistry, 2002
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.
Simoncic PD et al.
Current Biology : Cb, 2002
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.
Myers MP et al.
The Journal of Biological Chemistry, 2001
Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants.
Zhang YL et al.
The Journal of Biological Chemistry, 2000
Down-regulation of insulin signaling by protein-tyrosine phosphatase 1B is mediated by an N-terminal binding region.
Dadke S et al.
The Journal of Biological Chemistry, 2000
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases.
Flint AJ et al.
Proceedings of the National Academy of Sciences of the United States of America, 1997