Associated Papers
PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling.
Cen Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2026
Multiscale In Silico Study of the Mechanism of Activation of the RtcB Ligase by the PTP1B Phosphatase.
Mahdizadeh SJ et al.
Journal of Chemical Information and Modeling, 2024
Analysis of neutral mutational drift in an allosteric enzyme.
Liechty ET et al.
Protein Science : a Publication of the Protein Society, 2023
Structure guided studies of the interaction between PTP1B and JAK.
Morris R et al.
Communications Biology, 2023
Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Zeke A et al.
Nature Communications, 2022
Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.
Papaioannou A et al.
Life Science Alliance, 2022
The manifold roles of protein S-nitrosylation in the life of insulin.
Zhou HL et al.
Nature Reviews. Endocrinology, 2022
The PTP1B mutant PTP1B∆2-4 is a positive regulator of the JAK/STAT signalling pathway in Hodgkin lymphoma.
Zahn M et al.
Carcinogenesis, 2021
Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2.
Pádua RAP et al.
Nature Communications, 2018
Spatial regulation of signaling by the coordinated action of the protein tyrosine kinases MET and FER.
Zhang J et al.
Cellular Signalling, 2018
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Banh RS et al.
Nature Cell Biology, 2016
Cadherin 2/4 signaling via PTP1B and catenins is crucial for nucleokinesis during radial neuronal migration in the neocortex.
Martinez-Garay I et al.
Development (cambridge, England), 2016
Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.
Mei W et al.
Plos One, 2016
PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility.
González Wusener AE et al.
Biology Open, 2015
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.
Wang HM et al.
Cell Research, 2014
Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.
Sheriff S et al.
Journal of Medicinal Chemistry, 2011
The protein tyrosine phosphatase PTP1B is required for efficient delivery of N-cadherin to the cell surface.
Hernández MV et al.
Molecular Biology of the Cell, 2010
ER-bound PTP1B is targeted to newly forming cell-matrix adhesions.
Hernández MV et al.
Journal of Cell Science, 2006
Experimental validation of the docking orientation of Cdc25 with its Cdk2-CycA protein substrate.
Sohn J et al.
Biochemistry, 2005
Allosteric inhibition of protein tyrosine phosphatase 1B.
Wiesmann C et al.
Nature Structural & Molecular Biology, 2004
Continuous association of cadherin with beta-catenin requires the non-receptor tyrosine-kinase Fer.
Xu G et al.
Journal of Cell Science, 2004
The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking.
Ragab A et al.
The Journal of Biological Chemistry, 2003
Functional characterization and crystal structure of the C215D mutant of protein-tyrosine phosphatase-1B.
Romsicki Y et al.
The Journal of Biological Chemistry, 2003
Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor.
Sun JP et al.
The Journal of Biological Chemistry, 2003
Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant.
Xie L et al.
Biochemistry, 2002
The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change.
Scapin G et al.
Protein Science : a Publication of the Protein Society, 2001
The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase.
Asante-Appiah E et al.
The Journal of Biological Chemistry, 2001
Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin.
Rhee J et al.
The Journal of Biological Chemistry, 2001
Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants.
Zhang YL et al.
The Journal of Biological Chemistry, 2000
Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B.
Arregui CO et al.
The Journal of Cell Biology, 1998
Interconversion of the kinetic identities of the tandem catalytic domains of receptor-like protein-tyrosine phosphatase PTPalpha by two point mutations is synergistic and substrate-dependent.
Lim KL et al.
The Journal of Biological Chemistry, 1998
The nonreceptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherin-actin linkage.
Balsamo J et al.
The Journal of Cell Biology, 1998
Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B.
Sarmiento M et al.
The Journal of Biological Chemistry, 1998
The single sulfur to oxygen substitution in the active site nucleophile of the Yersinia protein-tyrosine phosphatase leads to substantial structural and functional perturbations.
Zhang ZY et al.
Biochemistry, 1997