Varaico: Literature-Extracted Genetic Variants

Gene:PTPN1
Variant:p.G381S
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PTPN1

NM_002827.4:p.G381S

Associated Papers

Structures of human protein tyrosine phosphatase variants reveal targetable allosteric sites.

Perdikari A et al.

The Journal of Biological Chemistry, 2025

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.

Perdikari A et al.

Biorxiv : the Preprint Server for Biology, 2025

Rare Tumor-Normal Matched Whole Exome Sequencing Identifies Novel Genomic Pathogenic Germline and Somatic Aberrations.

Sprissler R et al.

Cancers, 2020

32570879 (PubMed )
Supplement: cancers-12-01618-s001.zip › cancers-817200-Supplementary_Materials3 › Supplementary_table_S1.xlsx › TSG

Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma.

Gunawardana J et al.

Nature Genetics, 2014

Protein tyrosine phosphatase 1B is not a major susceptibility gene for type 2 diabetes mellitus or obesity among Pima Indians.

Traurig M et al.

Diabetologia, 2007

Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people.

Florez JC et al.

Diabetes, 2005

The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population.

Gouni-Berthold I et al.

Journal of Internal Medicine, 2005

A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro.

Echwald SM et al.

Diabetes, 2002

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."