Associated Papers
Deep mutational scanning of a multi-domain signaling protein reveals mechanisms of regulation and pathogenicity.
Jiang Z et al.
Biorxiv : the Preprint Server for Biology, 2024
39091798 (PubMed )
Supplement: media-3.xlsx › SHP2-FL_cSrc-KD_column
Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome.
Machado LESF et al.
Acs Omega, 2017
Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11).
Qiu W et al.
Bmc Structural Biology, 2014
Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase.
Darian E et al.
Proteins, 2011
Structural and functional effects of disease-causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP-2.
Bocchinfuso G et al.
Proteins, 2007
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