Varaico: Literature-Extracted Genetic Variants

Gene:PTPN11
Variant:p.K280E
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PTPN11

NM_002834.5:p.K280E

Associated Papers

Attenuating Mutations in Usutu Virus: Towards Understanding Orthoflavivirus Virulence Determinants and Live Attenuated Vaccine Design.

Duyvestyn JM et al.

Vaccines, 2025

40432107 (PubMed )
Supplement: vaccines-13-00495-s001.zip › vaccines-3557754-supplementary.pdf

Deep mutational scanning of a multi-domain signaling protein reveals mechanisms of regulation and pathogenicity.

Jiang Z et al.

Biorxiv : the Preprint Server for Biology, 2024

39091798 (PubMed )
Supplement: media-4.xlsx › SHP2-PTP_cSrc-KD_column

Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.

Zeke A et al.

Nature Communications, 2022

Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation.

Zhu G et al.

Cell, 2020

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."