Associated Papers
Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes.
LeBleu G et al.
Journal of Cellular Physiology, 2026
Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants.
van Vlimmeren AE et al.
Embo Reports, 2025
Age-related retinal degeneration resulting from the deletion of Shp2 tyrosine phosphatase in photoreceptor neurons.
Rajala A et al.
Cell Death & Disease, 2024
SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.
Chouhan S et al.
Nature Communications, 2024
An Integrated Proteomic Strategy to Identify SHP2 Substrates.
Zhu P et al.
Journal of Proteome Research, 2022
Effects of Noonan Syndrome-Germline Mutations on Mitochondria and Energy Metabolism.
Bajia D et al.
Cells, 2022
Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Zeke A et al.
Nature Communications, 2022
Deficiency of the Src homology phosphatase 2 in podocytes is associated with renoprotective effects in mice under hyperglycemia.
Hsu MF et al.
Cellular and Molecular Life Sciences : Cmls, 2022
A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2).
Hartman Z et al.
The Journal of Biological Chemistry, 2020
Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function.
Levy AD et al.
Cell Reports, 2018
Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.
Gurung P et al.
Immunity, 2017
Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling.
Noda S et al.
Biochemical and Biophysical Research Communications, 2016
Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells.
Furcht CM et al.
Journal of Cell Science, 2014
PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells.
Wu N et al.
International Journal of Oncology, 2013
Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder.
Xu D et al.
Plos One, 2013
The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation.
Timmerman I et al.
Molecular Biology of the Cell, 2012
SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.
Takahashi A et al.
Molecular Cell, 2011
Regulation of RhoA-dependent ROCKII activation by Shp2.
Lee HH et al.
The Journal of Cell Biology, 2008
Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3.
Burks J et al.
Oncogene, 2006
Mutation of Thr466 in SHP2 abolishes its phosphatase activity, but provides a new substrate-trapping mutant.
Merritt R et al.
Biochimica Et Biophysica Acta, 2006
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.
Kolli S et al.
The Journal of Biological Chemistry, 2004
Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).
Wheadon H et al.
The Biochemical Journal, 2003