Associated Papers
Regulation and activity of the phosphatase SHP2: SH2 domains, dephosphorylation activity, and beyond.
Pierotti CL et al.
Biochemical Society Transactions, 2026
Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes.
LeBleu G et al.
Journal of Cellular Physiology, 2026
Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants.
van Vlimmeren AE et al.
Embo Reports, 2025
Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants.
van Vlimmeren AE et al.
Biorxiv : the Preprint Server for Biology, 2025
SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2.
Cho HJ et al.
Embo Molecular Medicine, 2025
Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants.
van Vlimmeren AE et al.
Biorxiv : the Preprint Server for Biology, 2025
Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development.
Wang Q et al.
Elife, 2025
Decoding the selective mechanism behind a monobody inhibitor to the phosphatase domain of SHP2: insights from molecular dynamics simulations.
Wang Y et al.
Physical Chemistry Chemical Physics : Pccp, 2025
Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development.
Wang Q et al.
Biorxiv : the Preprint Server for Biology, 2025
Computational Elucidation of a Monobody Targeting the Phosphatase Domain of SHP2.
Wang Y et al.
Biomolecules, 2025
Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2.
Makrides N et al.
Biorxiv : the Preprint Server for Biology, 2025
T Lymphocyte-Specific Deletion of SHP1 and SHP2 Promotes Activation-Induced Cell Death of CD4+ T Cells and Impairs Antitumor Response.
Foster CJR et al.
Biorxiv : the Preprint Server for Biology, 2025
Age-related retinal degeneration resulting from the deletion of Shp2 tyrosine phosphatase in photoreceptor neurons.
Rajala A et al.
Cell Death & Disease, 2024
SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.
Chouhan S et al.
Nature Communications, 2024
SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD.
Lee S et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition.
Lai X et al.
Npj Precision Oncology, 2023
Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC).
Richards CE et al.
International Journal of Molecular Sciences, 2023
Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation.
Sha F et al.
Journal of Molecular Biology, 2023
Setting sail: Maneuvering SHP2 activity and its effects in cancer.
Welsh CL et al.
Advances in Cancer Research, 2023
An Integrated Proteomic Strategy to Identify SHP2 Substrates.
Zhu P et al.
Journal of Proteome Research, 2022
Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Zeke A et al.
Nature Communications, 2022
Deficiency of the Src homology phosphatase 2 in podocytes is associated with renoprotective effects in mice under hyperglycemia.
Hsu MF et al.
Cellular and Molecular Life Sciences : Cmls, 2022
Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state.
Lin CC et al.
Molecular Cell, 2022
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis.
Zhu Y et al.
Embo Molecular Medicine, 2022
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.
Gebregiworgis T et al.
Nature Communications, 2021
SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS-STING Activation and Chemotherapeutic Sensitivity in Colon Cancer.
Wei B et al.
Cancer Research, 2021
Grb2 binding induces phosphorylation-independent activation of Shp2.
Lin CC et al.
Communications Biology, 2021
Case Report: Molecular Characterization of Aggressive Malignant Retroperitoneal Solitary Fibrous Tumor: A Case Study.
Nonaka H et al.
Frontiers in Oncology, 2021
Phosphatase-independent functions of SHP2 and its regulation by small molecule compounds.
Guo W et al.
Journal of Pharmacological Sciences, 2020
The YAP-Interacting Phosphatase SHP2 Can Regulate Transcriptional Coactivity and Modulate Sensitivity to Chemotherapy in Cholangiocarcinoma.
Buckarma EH et al.
Molecular Cancer Research : Mcr, 2020
The Noonan syndrome-associated D61G variant of the protein tyrosine phosphatase SHP2 prevents synaptic down-scaling.
Lu W et al.
The Journal of Biological Chemistry, 2020
Therapeutic potential of targeting SHP2 in human developmental disorders and cancers.
Shen D et al.
European Journal of Medicinal Chemistry, 2020
A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2).
Hartman Z et al.
The Journal of Biological Chemistry, 2020
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Kano Y et al.
Nature Communications, 2019
Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2.
Pádua RAP et al.
Nature Communications, 2018
Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function.
Levy AD et al.
Cell Reports, 2018
SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.
Mainardi S et al.
Nature Medicine, 2018
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess DA et al.
Nature Medicine, 2018
Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
Zheng H et al.
Science Signaling, 2018
New structural and functional insight into the regulation of Ras.
Kano Y et al.
Seminars in Cell & Developmental Biology, 2016
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Chen YN et al.
Nature, 2016
Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents.
Tsai WB et al.
Oncogene, 2016