Varaico: Literature-Extracted Genetic Variants

Gene:PTPN11
Variant:p.T466A
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PTPN11

NM_002834.5:p.T466A

Associated Papers

Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants.

van Vlimmeren AE et al.

Embo Reports, 2025

Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2.

Park H et al.

Bmb Reports, 2015

Mutation of Thr466 in SHP2 abolishes its phosphatase activity, but provides a new substrate-trapping mutant.

Merritt R et al.

Biochimica Et Biophysica Acta, 2006

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."