Varaico: Literature-Extracted Genetic Variants

Gene:PTPN2
Variant:p.D182A
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PTPN2

NM_002828.4:p.D182A

Associated Papers

Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes.

LeBleu G et al.

Journal of Cellular Physiology, 2026

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.

Svensson MN et al.

The Journal of Clinical Investigation, 2019

The tyrosine phosphatase TC48 interacts with and inactivates the oncogenic fusion protein BCR-Abl but not cellular Abl.

Mitra A et al.

Biochimica Et Biophysica Acta, 2013

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.

Wiede F et al.

The Journal of Clinical Investigation, 2011

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.

Kleppe M et al.

Nature Genetics, 2010

The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase.

Wang S et al.

The Journal of Biological Chemistry, 2006

Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases.

Chong YP et al.

Biochimica Et Biophysica Acta, 2005

Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.

van Vliet C et al.

Nature Immunology, 2005

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP.

Galic S et al.

Molecular and Cellular Biology, 2003

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.

Simoncic PD et al.

Current Biology : Cb, 2002

The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor.

Klingler-Hoffmann M et al.

The Journal of Biological Chemistry, 2001

Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.

Tiganis T et al.

Molecular and Cellular Biology, 1998

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."