Associated Papers
Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex.
Gupta K et al.
Embo Reports, 2025
A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.
Chang HH et al.
Jci Insight, 2016
Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus.
Chang HH et al.
Arthritis Research & Therapy, 2014
Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.
Bottini N et al.
Annual Review of Immunology, 2014
Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate.
Yu X et al.
The Journal of Biological Chemistry, 2011
The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation.
Hill RJ et al.
Experimental Hematology, 2002
Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase.
Cloutier JF et al.
The Journal of Experimental Medicine, 1999
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