Varaico: Literature-Extracted Genetic Variants

Gene:PTPN6
Variant:p.D419A
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PTPN6

NM_002831.6:p.D419A

Associated Papers

Regulation of PPARγ2 Stability and Activity by SHP-1.

Kumar A et al.

Molecular and Cellular Biology, 2024

SHP-1 phosphatase acts as a coactivator of PCK1 transcription to control gluconeogenesis.

Kumar A et al.

The Journal of Biological Chemistry, 2023

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

Gurung P et al.

Immunity, 2017

The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cells.

Ganesan LP et al.

The Journal of Biological Chemistry, 2003

Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor.

Bellón T et al.

Journal of Immunology (baltimore, Md. : 1950), 2002

Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells.

Xie ZH et al.

Journal of Immunology (baltimore, Md. : 1950), 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."