Varaico: Literature-Extracted Genetic Variants

Gene:PTPN6
Variant:p.Y536F
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PTPN6

NM_002831.6:p.Y536F

Associated Papers

THEMIS increases TCR signaling in CD4+CD8+ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1.

Choi S et al.

Science Signaling, 2023

A THEMIS:SHP1 complex promotes T-cell survival.

Paster W et al.

The Embo Journal, 2015

25535246 (PubMed )
Supplement: embj0034-0393-sd11.pdf

Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells.

Ozawa T et al.

International Immunology, 2007

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