Varaico: Literature-Extracted Genetic Variants

Gene:PXN
Variant:p.Y118F
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PXN

NM_001385981.1:p.Y118F

Associated Papers

Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt.

Huang Y et al.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 2020

Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung cancers via modulating BIM and Mcl-1 protein stability.

Wu DW et al.

Oncogene, 2016

Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway.

Coló GP et al.

Journal of Cell Science, 2012

EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118.

Vindis C et al.

The Journal of Biological Chemistry, 2004

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.

Zhang SQ et al.

Molecular Cell, 2004

Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal.

Sastry SK et al.

The Journal of Cell Biology, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."