Associated Papers
Distinct interaction modes orchestrate the polymerization of ASC PYD and CARD domains into filamentous structures.
Otas HO et al.
The Febs Journal, 2026
Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome Activation for IL-1β Production.
Borrego A et al.
Frontiers in Immunology, 2022
Comprehensive review of ASC structure and function in immune homeostasis and disease.
Agrawal I et al.
Molecular Biology Reports, 2020
The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments.
Vajjhala PR et al.
The Journal of Biological Chemistry, 2015
Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly.
Vajjhala PR et al.
The Journal of Biological Chemistry, 2014
Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation.
Cai X et al.
Cell, 2014
Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.
Vajjhala PR et al.
The Journal of Biological Chemistry, 2012
Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC.
Moriya M et al.
Biochemistry, 2005
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