Varaico: Literature-Extracted Genetic Variants

Gene:RAB8A
Variant:p.T72A
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RAB8A

NM_005370.5:p.T72A

Associated Papers

LRRK2 kinase modulates glucose-stimulated insulin secretion via RAB8 phosphorylation and ciliogenesis.

Dule N et al.

Cellular and Molecular Life Sciences : Cmls, 2025

Inhibition of the Exocyst Complex Attenuates the LRRK2 Pathological Effects.

Ciampelli C et al.

International Journal of Molecular Sciences, 2023

LRRK2 activation controls the repair of damaged endomembranes in macrophages.

Herbst S et al.

The Embo Journal, 2020

32643832 (PubMed )
Supplement: EMBJ-39-e104494-s002.pdf

The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A.

Rivero-Ríos P et al.

The Journal of Biological Chemistry, 2019

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

Steger M et al.

Elife, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."