Associated Papers
New insights into the classification of the RAC1 P29S hotspot mutation in melanoma as an oncogene.
Mirzaiebadizi A et al.
Cancer Gene Therapy, 2025
Accurate affinity models for SH2 domains from peptide binding assays and free-energy regression.
Gagoski D et al.
Protein Science : a Publication of the Protein Society, 2025
41088778 (PubMed )
Supplement: PRO-34-e70317-s008.xlsx › _S6_-_PTMVar_-_Lyn
Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression.
Gagoski D et al.
Biorxiv : the Preprint Server for Biology, 2025
39764007 (PubMed )
Supplement: media-1.xlsx › _S6_-_PTMVar_-_Lyn
The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis.
Conde J et al.
Molecular Oncology, 2025
Tumor-derived RHOA mutants interact with effectors in the GDP-bound state.
Lin Y et al.
Nature Communications, 2024
Wavelet coherence phase analysis decodes the universal switching mechanism of Ras GTPase superfamily.
Motiwala Z et al.
Iscience, 2023
37448564 (PubMed )
Supplement: mmc2.xlsx › Sheet1
Molecular simulation unravels the amyloidogenic misfolding of nascent ApoA1 protein, driven by deleterious point mutations occurring in between 170-178 hotspot region.
Chandrasekhar G et al.
Journal of Biomolecular Structure & Dynamics, 2022
RAC1 Alterations Induce Acquired Dabrafenib Resistance in Association with Anaplastic Transformation in a Papillary Thyroid Cancer Patient.
Bagheri-Yarmand R et al.
Cancers, 2021
RAC1P29S is a spontaneously activating cancer-associated GTPase.
Davis MJ et al.
Proceedings of the National Academy of Sciences of the United States of America, 2013
Molecular dynamic simulation reveals damaging impact of RAC1 F28L mutation in the switch I region.
Kumar A et al.
Plos One, 2013
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Krauthammer M et al.
Nature Genetics, 2012
Select a paper to view details