Associated Papers
Rac1 selectively binds a specific lamellipodin isoform via a noncanonical helical interface.
Gao T et al.
The Journal of Biological Chemistry, 2026
Thymic egress and peripheral T cell homeostasis regulated by Rho GTPase-activating protein 30.
Zhang H et al.
Cell Death and Differentiation, 2025
The emerging role of disulfidptosis in Alzheimer's disease.
Zhou Q et al.
European Journal of Pharmacology, 2025
TIMP1 inhibits Rac1-mediated ROS production to ameliorate blood-spinal cord barrier disruption in amyotrophic lateral sclerosis.
Tang J et al.
Neurobiology of Disease, 2025
Diverse Clinical Presentation of RAC1-Related Intellectual Developmental Disorder.
Upadia J et al.
American Journal of Medical Genetics. Part A, 2025
FLNA regulates neuronal maturation by modulating RAC1-Cofilin activity in the developing cortex.
Falace A et al.
Neurobiology of Disease, 2024
Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints.
Cannon AC et al.
Oncogene, 2024
GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress.
Zhou W et al.
Cancer Discovery, 2024
Twist family BHLH transcription factor 1 is required for the maintenance of leukemia stem cell in MLL-AF9+ acute myeloid leukemia.
Wang N et al.
Haematologica, 2024
Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases.
Cheng X et al.
Nature Communications, 2023
PPP2R1A regulates migration persistence through the NHSL1-containing WAVE Shell Complex.
Wang Y et al.
Nature Communications, 2023
GTP signaling links metabolism, DNA repair, and responses to genotoxic stress.
Zhou W et al.
Biorxiv : the Preprint Server for Biology, 2023
Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis.
Xing L et al.
Journal of Cell Communication and Signaling, 2023
In silico identification and characterization of small-molecule inhibitors specific to RhoG/Rac1 signaling pathway.
Dipankar P et al.
Journal of Biomolecular Structure & Dynamics, 2023
De Novo Somatic Mosaicism of CYBB Caused by Intronic LINE-1 Element Insertion Resulting in Chronic Granulomatous Disease.
Yu L et al.
Journal of Clinical Immunology, 2023
Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology.
Banka S et al.
Brain : a Journal of Neurology, 2022
Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for Distinct Pathways of Molecular Pathogenesis.
Russell-Goldman E et al.
The American Journal of Dermatopathology, 2022
TMED2 binding restricts SMO to the ER and Golgi compartments.
Di Minin G et al.
Plos Biology, 2022
Fine definition of the epitopes on the human gp91phox/NOX2 for the monoclonal antibodies CL-5 and 48.
Kawai C et al.
Journal of Immunological Methods, 2022
Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.
Robles-Valero J et al.
The Embo Journal, 2021
TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation.
Kolliopoulos C et al.
Cancers, 2021
Cellular Models and High-Throughput Screening for Genetic Causality of Intellectual Disability.
Fell CW et al.
Trends in Molecular Medicine, 2021
A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and Autophagy.
Sheng YH et al.
Cellular and Molecular Gastroenterology and Hepatology, 2021
NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation.
Wei Y et al.
Embo Reports, 2020
Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis.
Rodríguez-Fdez S et al.
Nature Communications, 2020
Fibulin 5, a human Wharton's jelly-derived mesenchymal stem cells-secreted paracrine factor, attenuates peripheral nervous system myelination defects through the Integrin-RAC1 signaling axis.
Won SY et al.
Stem Cells (dayton, Ohio), 2020
The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2.
Arrington ME et al.
The Journal of Biological Chemistry, 2020
Pre-Treatment Mutational and Transcriptomic Landscape of Responding Metastatic Melanoma Patients to Anti-PD1 Immunotherapy.
Amato CM et al.
Cancers, 2020
RAC1 as a Therapeutic Target in Malignant Melanoma.
Cannon AC et al.
Trends in Cancer, 2020
Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42.
Gorisse L et al.
The Journal of Biological Chemistry, 2020
mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in IDH1-Mutated Glioma.
Liu Y et al.
Cancers, 2020
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
Bagci H et al.
Nature Cell Biology, 2020
RAC1B: A Guardian of the Epithelial Phenotype and Protector Against Epithelial-Mesenchymal Transition.
Zinn R et al.
Cells, 2019
RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance.
Lionarons DA et al.
Cancer Cell, 2019
Epigenetic Regulation of the PTEN-AKT-RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma.
Bhat AV et al.
Cancer Research, 2019
De novo missense variants in RAC3 cause a novel neurodevelopmental syndrome.
Costain G et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2019
CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors.
Whitelaw JA et al.
Communicative & Integrative Biology, 2019
Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo.
Schaks M et al.
Current Biology : Cb, 2018
Induction of non-apoptotic programmed cell death by oncogenic RAS in human epithelial cells and its suppression by MYC overexpression.
Dendo K et al.
Carcinogenesis, 2018