Associated Papers
Accurate affinity models for SH2 domains from peptide binding assays and free-energy regression.
Gagoski D et al.
Protein Science : a Publication of the Protein Society, 2025
41088778 (PubMed )
Supplement: PRO-34-e70317-s008.xlsx › _S6_-_PTMVar_-_Lyn
A Pleiotropic and Functionally Divergent RAC3 Variant Disrupts Neurodevelopment and Impacts Organogenesis.
Sugawara R et al.
Cells, 2025
A p.N92K variant of the GTPase RAC3 disrupts cortical neuron migration and axon elongation.
Sugawara R et al.
The Journal of Biological Chemistry, 2025
Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression.
Gagoski D et al.
Biorxiv : the Preprint Server for Biology, 2025
39764007 (PubMed )
Supplement: media-1.xlsx › _S6_-_PTMVar_-_Lyn
The p.R66W Variant in RAC3 Causes Severe Fetopathy Through Variant-Specific Mechanisms.
Sugawara R et al.
Cells, 2024
Gain-of-function p.F28S variant in RAC3 disrupts neuronal differentiation, migration and axonogenesis during cortical development, leading to neurodevelopmental disorder.
Nishikawa M et al.
Journal of Medical Genetics, 2023
Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes.
Scala M et al.
Brain : a Journal of Neurology, 2022
Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What's behind Neuro-RACopathies.
Scala M et al.
Cells, 2021
Genome Sequencing as a Diagnostic Test in Children With Unexplained Medical Complexity.
Costain G et al.
Jama Network Open, 2020
A de novo variant in RAC3 causes severe global developmental delay and a middle interhemispheric variant of holoprosencephaly.
Hiraide T et al.
Journal of Human Genetics, 2019
De novo missense variants in RAC3 cause a novel neurodevelopmental syndrome.
Costain G et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2019
Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo.
Schaks M et al.
Current Biology : Cb, 2018
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