Associated Papers
RAD50 missense variants differentially affect the DNA damage response and mitotic progression.
Redeker H et al.
Febs Letters, 2025
Germline Cancer Susceptibility Variants in Patients With Uveal Melanoma.
Repo PE et al.
Pigment Cell & Melanoma Research, 2025
Population-based study of recurrent DNA damage response gene variants in breast cancer cases.
Tervasmäki A et al.
Breast Cancer Research and Treatment, 2025
Risk of lymphoid malignancy associated with cancer predisposition genes.
Boddicker NJ et al.
Blood Cancer Journal, 2025
Germline pathogenic variants in the MRE11, RAD50, and NBN (MRN) genes in cancer predisposition: A systematic review and meta-analysis.
Stastna B et al.
International Journal of Cancer, 2024
Multigenic panels in breast cancer: Clinical utility and management of patients with pathogenic variants other than BRCA1/2.
Fabi A et al.
Critical Reviews in Oncology/hematology, 2024
Predicted deleterious variants in the human genome relevant to gene therapy with adeno-associated virus vectors.
Rostami MR et al.
Molecular Therapy. Methods & Clinical Development, 2023
A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model.
Chisada S et al.
Plos One, 2023
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations.
Qin Z et al.
Life Science Alliance, 2022
Germline breast cancer susceptibility genes, tumor characteristics, and survival.
Ho PJ et al.
Genome Medicine, 2021
MRN Complex and Cancer Risk: Old Bottles, New Wine.
Elkholi IE et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2021
RAD50 Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma.
Ko JMY et al.
Cancers, 2021
Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications.
Toh M et al.
The Oncologist, 2021
A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex.
Rahman S et al.
Cells, 2020
Familial/inherited cancer syndrome: a focus on the highly consanguineous Arab population.
AlHarthi FS et al.
Npj Genomic Medicine, 2020
Delineation of the Germline and Somatic Mutation Interaction Landscape in Triple-Negative and Non-Triple-Negative Breast Cancer.
Wu J et al.
International Journal of Genomics, 2020
The GenomeAsia 100K Project enables genetic discoveries across Asia.
Unknown Author
Nature, 2019
Deconvolution of the Genomic and Epigenomic Interaction Landscape of Triple-Negative Breast Cancer.
Wu J et al.
Cancers, 2019
RAD50 germline mutations are associated with poor survival in BRCA1/2-negative breast cancer patients.
Fan C et al.
International Journal of Cancer, 2018
Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility.
Mantere T et al.
Scientific Reports, 2017
Pathogenic variant burden in the ExAC database: an empirical approach to evaluating population data for clinical variant interpretation.
Kobayashi Y et al.
Genome Medicine, 2017
Frequency of pathogenic germline mutation in CHEK2, PALB2, MRE11, and RAD50 in patients at high risk for hereditary breast cancer.
Kim H et al.
Breast Cancer Research and Treatment, 2017
Routine use of gene panel testing in hereditary breast cancer should be performed with caution.
van Marcke C et al.
Critical Reviews in Oncology/hematology, 2016
Estimating cumulative risks for breast cancer for carriers of variants in uncommon genes.
Lindor NM et al.
Familial Cancer, 2016
Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
Couch FJ et al.
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2015
Beyond BRCA: new hereditary breast cancer susceptibility genes.
Economopoulou P et al.
Cancer Treatment Reviews, 2015
Hereditary ovarian cancer: not only BRCA 1 and 2 genes.
Toss A et al.
Biomed Research International, 2015
Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study.
Damiola F et al.
Breast Cancer Research : Bcr, 2014
Next-generation sequencing for inherited breast cancer risk: counseling through the complexity.
Rainville IR et al.
Current Oncology Reports, 2014
Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia.
Mosor M et al.
Bmc Cancer, 2013
The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.
Ziółkowska-Suchanek I et al.
Molecular Cancer, 2013
Hereditary breast cancer in the Han Chinese population.
Cao W et al.
Journal of Epidemiology, 2013
RAD50 and NBS1 are not likely to be susceptibility genes in Chinese non-BRCA1/2 hereditary breast cancer.
He M et al.
Breast Cancer Research and Treatment, 2012
Defective homologous recombination in human cancers.
Cerbinskaite A et al.
Cancer Treatment Reviews, 2012
Inherited mutations in breast cancer genes--risk and response.
Shuen AY et al.
Journal of Mammary Gland Biology and Neoplasia, 2011
RAD50 gene mutations are not likely a risk factor for breast cancer in Poland.
Mosor M et al.
Breast Cancer Research and Treatment, 2010
Some common mutations of RAD50 and NBS1 in western populations do not contribute significantly to Chinese non-BRCA1/2 hereditary breast cancer.
Cao AY et al.
Breast Cancer Research and Treatment, 2010
Breast cancer susceptibility: current knowledge and implications for genetic counselling.
Ripperger T et al.
European Journal of Human Genetics : Ejhg, 2009
Rad50 c.687delT does not contribute significantly to familial breast cancer in a French population.
Uhrhammer N et al.
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2009
Hereditary breast cancer: new genetic developments, new therapeutic avenues.
Campeau PM et al.
Human Genetics, 2008
Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair.
Czornak K et al.
Journal of Applied Genetics, 2008
Links between DNA double strand break repair and breast cancer: accumulating evidence from both familial and nonfamilial cases.
Ralhan R et al.
Cancer Letters, 2007