Associated Papers
Rad51 determines pathway usage in post-replication repair.
Meyer D et al.
Nature Communications, 2026
RAD51-mediated homologous recombination is a pro-tumour driver pathway.
Lopez BS
Oncogene, 2025
Distinct roles of RECQL5 in RAD51-mediated fork reversal and transcription elongation.
Nagraj T et al.
Nucleic Acids Research, 2025
RAD51-Related Fanconi Anemia: Expanding the Phenotypic Spectrum and Strong Association With VACTERL.
Altintas B et al.
Clinical Genetics, 2025
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.
Ceppi I et al.
Nature, 2024
(Single-stranded DNA) gaps in understanding BRCAness.
Schreuder A et al.
Trends in Genetics : Tig, 2024
RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes.
Dixit S et al.
Cell Reports, 2024
RAD52 prevents accumulation of Polα -dependent replication gaps at perturbed replication forks in human cells.
Di Biagi L et al.
Biorxiv : the Preprint Server for Biology, 2024
BRCAness, DNA gaps, and gain and loss of PARP inhibitor-induced synthetic lethality.
Li X et al.
The Journal of Clinical Investigation, 2024
RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair.
Son MY et al.
Iscience, 2024
Pathogenic variants in human DNA damage repair genes mostly arose in recent human history.
Zhao B et al.
Bmc Cancer, 2024
Fanconi anemia-associated mutation in RAD51 compromises the coordinated action of DNA-binding and ATPase activities.
Liu S et al.
The Journal of Biological Chemistry, 2023
RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases.
Guh CL et al.
Nucleic Acids Research, 2023
In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis.
Matos-Rodrigues G et al.
The Embo Journal, 2023
FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability.
Liu W et al.
Nucleic Acids Research, 2023
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages.
Chakraborty S et al.
Dna Repair, 2023
RAD51 bypasses the CMG helicase to promote replication fork reversal.
Liu W et al.
Science (new York, N.y.), 2023
A novel RAD51 variant resulting in Fanconi anemia identified in an infant with multiple congenital anomalies.
Geilmann S et al.
Clinical Case Reports, 2023
RAD51 paralogs: Expanding roles in replication stress responses and repair.
Bhattacharya D et al.
Current Opinion in Pharmacology, 2022
Double-stranded DNA binding function of RAD51 in DNA protection and its regulation by BRCA2.
Halder S et al.
Molecular Cell, 2022
BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair.
Jimenez-Sainz J et al.
Elife, 2022
RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function.
So A et al.
Nucleic Acids Research, 2022
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells.
Tirman S et al.
Molecular Cell, 2021
The RAD51 recombinase protects mitotic chromatin in human cells.
Wassing IE et al.
Nature Communications, 2021
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
Cong K et al.
Molecular Cell, 2021
RAD51: Beyond the break.
Wassing IE et al.
Seminars in Cell & Developmental Biology, 2021
Replication Gaps Underlie BRCA Deficiency and Therapy Response.
Panzarino NJ et al.
Cancer Research, 2021
Which Holds the Key to BRCAness: Inability to Repair the Break, Protect the Fork, or Prevent the Gap?
Canman CE
Cancer Research, 2021
RAD51 Gene Family Structure and Function.
Bonilla B et al.
Annual Review of Genetics, 2020
Two replication fork remodeling pathways generate nuclease substrates for distinct fork protection factors.
Liu W et al.
Science Advances, 2020
Emerging functions of Fanconi anemia genes in replication fork protection pathways.
Kolinjivadi AM et al.
Human Molecular Genetics, 2020
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.
Berti M et al.
Nature Communications, 2020
Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links.
Rickman KA et al.
Genes & Development, 2020
The canine RAD51 mutation leads to the attenuation of interaction with PALB2.
Uemura M et al.
Veterinary and Comparative Oncology, 2020
Role of Rad51 and DNA repair in cancer: A molecular perspective.
Laurini E et al.
Pharmacology & Therapeutics, 2020
Non-enzymatic roles of human RAD51 at stalled replication forks.
Mason JM et al.
Nature Communications, 2019
Proteolytic control of genome integrity at the replication fork.
Rageul J et al.
Dna Repair, 2019
A Japanese patient with RAD51-associated Fanconi anemia.
Takenaka S et al.
American Journal of Medical Genetics. Part A, 2019
Characterization of a potent dominant negative mutant variant of Rad51 in Ustilago maydis.
Sutherland JH et al.
Dna Repair, 2019
Advances in understanding DNA processing and protection at stalled replication forks.
Rickman K et al.
The Journal of Cell Biology, 2019
Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.
Burrage LC et al.
American Journal of Human Genetics, 2019
The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.
Marzio A et al.
Molecular Cell, 2019
A tough row to hoe: when replication forks encounter DNA damage.
Patel DR et al.
Biochemical Society Transactions, 2018
Preserving replication fork integrity and competence via the homologous recombination pathway.
Ait Saada A et al.
Dna Repair, 2018