Associated Papers
RAD51AP1 is a versatile RAD51 modulator.
Kuhlen L et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
RAD51-mediated homologous recombination is a pro-tumour driver pathway.
Lopez BS
Oncogene, 2025
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments.
Kuthethur R et al.
Science (new York, N.y.), 2025
Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin.
Carver A et al.
Science (new York, N.y.), 2025
Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA.
Akita M et al.
Nucleic Acids Research, 2024
Replication fork stalling in late S-phase elicits nascent strand degradation by DNA mismatch repair.
Colicino-Murbach E et al.
Nucleic Acids Research, 2024
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.
Ceppi I et al.
Nature, 2024
Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin.
Carver A et al.
Biorxiv : the Preprint Server for Biology, 2024
The mutagenic consequences of defective DNA repair.
Németh E et al.
Dna Repair, 2024
RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair.
Son MY et al.
Iscience, 2024
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.
Ye Z et al.
Nature Communications, 2024
RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases.
Guh CL et al.
Nucleic Acids Research, 2023
In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis.
Matos-Rodrigues G et al.
The Embo Journal, 2023
CRISPR-dependent Base Editing Screens Identify Separation of Function Mutants of RADX with Altered RAD51 Regulatory Activity.
Adolph MB et al.
Journal of Molecular Biology, 2023
RAD51 bypasses the CMG helicase to promote replication fork reversal.
Liu W et al.
Science (new York, N.y.), 2023
Double-stranded DNA binding function of RAD51 in DNA protection and its regulation by BRCA2.
Halder S et al.
Molecular Cell, 2022
MicroRNA-449a Inhibits Triple Negative Breast Cancer by Disturbing DNA Repair and Chromatid Separation.
Vajen B et al.
International Journal of Molecular Sciences, 2022
Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends.
Schaub JM et al.
Nucleic Acids Research, 2022
RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function.
So A et al.
Nucleic Acids Research, 2022
The RAD51 recombinase protects mitotic chromatin in human cells.
Wassing IE et al.
Nature Communications, 2021
Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.
Prakash R et al.
Nature Communications, 2021
RAD51: Beyond the break.
Wassing IE et al.
Seminars in Cell & Developmental Biology, 2021
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins.
Belan O et al.
Molecular Cell, 2021
RADX controls RAD51 filament dynamics to regulate replication fork stability.
Adolph MB et al.
Molecular Cell, 2021
DCAF14 promotes stalled fork stability to maintain genome integrity.
Townsend A et al.
Cell Reports, 2021
Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates.
Xue C et al.
Nucleic Acids Research, 2021
Two replication fork remodeling pathways generate nuclease substrates for distinct fork protection factors.
Liu W et al.
Science Advances, 2020
Non-enzymatic roles of human RAD51 at stalled replication forks.
Mason JM et al.
Nature Communications, 2019
Characterization of a potent dominant negative mutant variant of Rad51 in Ustilago maydis.
Sutherland JH et al.
Dna Repair, 2019
Advances in understanding DNA processing and protection at stalled replication forks.
Rickman K et al.
The Journal of Cell Biology, 2019
Loss of Cohesin Subunit Rec8 Switches Rad51 Mediator Dependence in Resistance to Formaldehyde Toxicity in Ustilago maydis.
Sutherland JH et al.
Genetics, 2018
Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state.
Špírek M et al.
Nucleic Acids Research, 2018