Associated Papers
Circulating cell-free DNA profiling reveals ancestry-dependent genetic variation in metastatic prostate cancer.
Maleknia S et al.
Molecular Biomedicine, 2026
Analytical Validation and Clinical Sensitivity of the Belay Summit™ 2.0 Cerebrospinal Fluid Liquid Biopsy Test-An Expanded Comprehensive Genomic Profiling Platform for Central Nervous System Malignancies.
Khurana S et al.
Cancers, 2026
Germline predisposition in multiple myeloma.
Martins Rodrigues F et al.
Iscience, 2025
Engineering of a high-fidelity Cas12a nuclease variant capable of allele-specific editing.
Wei J et al.
Plos Biology, 2024
Pathogenic variants in human DNA damage repair genes mostly arose in recent human history.
Zhao B et al.
Bmc Cancer, 2024
Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and novel associations between genomic alterations, TMB, and PD-L1.
Wallen ZD et al.
Frontiers in Oncology, 2024
Rare genetic variants involved in multisystem inflammatory syndrome in children: a multicenter Brazilian cohort study.
Reis BCSD et al.
Frontiers in Cellular and Infection Microbiology, 2023
Clinical and genomic features of Chinese lung cancer patients with germline mutations.
Peng W et al.
Nature Communications, 2022
Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications.
Toh M et al.
The Oncologist, 2021
Homologous recombination, cancer and the 'RAD51 paradox'.
Matos-Rodrigues G et al.
Nar Cancer, 2021
Assessment of Clinical Benefit of Integrative Genomic Profiling in Advanced Solid Tumors.
Cobain EF et al.
Jama Oncology, 2021
High-depth African genomes inform human migration and health.
Choudhury A et al.
Nature, 2020
Detection of Germline Mutations in Breast Cancer Patients with Clinical Features of Hereditary Cancer Syndrome Using a Multi-Gene Panel Test.
Shin HC et al.
Cancer Research and Treatment, 2020
The canine RAD51 mutation leads to the attenuation of interaction with PALB2.
Uemura M et al.
Veterinary and Comparative Oncology, 2020
Reinterpretation of common pathogenic variants in ClinVar revealed a high proportion of downgrades.
Xiang J et al.
Scientific Reports, 2020
Characterization of a potent dominant negative mutant variant of Rad51 in Ustilago maydis.
Sutherland JH et al.
Dna Repair, 2019
Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors.
Lee JW et al.
Plos One, 2019
Discovery of mutations in homologous recombination genes in African-American women with breast cancer.
Ding YC et al.
Familial Cancer, 2018
Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy.
van der Zon NL et al.
F1000research, 2018
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs.
Jiang S et al.
Frontiers in Genetics, 2018
Homologous recombination defects and how they affect replication fork maintenance.
Son MY et al.
Aims Genetics, 2018
Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein.
Silva MC et al.
Dna Repair, 2017
Frequent inactivating germline mutations in DNA repair genes in patients with Ewing sarcoma.
Brohl AS et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2017
FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end.
Sato K et al.
Nucleic Acids Research, 2016
iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.
Wang M et al.
Scientific Reports, 2016
The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.
Marsden CG et al.
Plos Genetics, 2016
Multigene testing of moderate-risk genes: be mindful of the missense.
Young EL et al.
Journal of Medical Genetics, 2016
RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects.
Silva MC et al.
Dna Repair, 2016
Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.
Chen J et al.
Nucleic Acids Research, 2015
The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation.
Brohl AS et al.
Plos Genetics, 2014
RAD51 and breast cancer susceptibility: no evidence for rare variant association in the Breast Cancer Family Registry study.
Le Calvez-Kelm F et al.
Plos One, 2012
Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51.
Takaku M et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2011
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Ishida T et al.
Nucleic Acids Research, 2009
Altered DNA binding by the human Rad51-R150Q mutant found in breast cancer patients.
Ishida T et al.
Biological & Pharmaceutical Bulletin, 2007
Variation in the RAD51 gene and familial breast cancer.
Lose F et al.
Breast Cancer Research : Bcr, 2006
The RAD51 gene family, genetic instability and cancer.
Thacker J
Cancer Letters, 2005