Associated Papers
DA-Raf synergistically binds to the plasma membrane and Ras to suppress ERK signaling.
Takano K et al.
Life Science Alliance, 2025
Characterization of MEK1/2 Degraders Uncovers a Kinase-Independent Role for MEK1/2 in the Stabilization and Maturation of CRAF.
Wasserman JS et al.
Biorxiv : the Preprint Server for Biology, 2025
In-cell single-molecule FRET measurement of cytosolic RAF proteins to investigate the structural states and kinetics among them.
Okamoto K et al.
Frontiers in Molecular Biosciences, 2025
RAF1 gene fusions are recurrent driver events in infantile fibrosarcoma-like mesenchymal tumors.
Motta M et al.
The Journal of Pathology, 2024
Bioluminescence Resonance Energy Transfer (BRET)-based Assay for Measuring Interactions of CRAF with 14-3-3 Proteins in Live Cells.
Spencer-Smith R
Journal of Visualized Experiments : Jove, 2024
RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa.
Chessel A et al.
Nature Communications, 2023
Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase.
Rohrer L et al.
Cell Communication and Signaling : Ccs, 2023
Two Closed Conformations of CRAF Require the 14-3-3 Binding Motifs and Cysteine-Rich Domain to be Intact in Live Cells.
Okamoto K et al.
Journal of Molecular Biology, 2023
Comparative analysis of functional assay evidence use by ClinGen Variant Curation Expert Panels.
Kanavy DM et al.
Genome Medicine, 2019
The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho-Ser-621 in the C terminus of CRAF.
Yuan J et al.
The Journal of Biological Chemistry, 2018
Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1.
Thomas SV et al.
The Journal of Biological Chemistry, 2011
Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.
Kobayashi T et al.
Human Mutation, 2010
Spry2 does not directly modulate Raf-1 kinase activity in v-Ha-ras-transformed NIH 3T3 fibroblasts.
Ahn JH et al.
Bmb Reports, 2010
The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch.
Dhillon AS et al.
Cellular Signalling, 2009
A RasGTP-induced conformational change in C-RAF is essential for accurate molecular recognition.
Hibino K et al.
Biophysical Journal, 2009
Characterization of Ser338 phosphorylation for Raf-1 activation.
Zang M et al.
The Journal of Biological Chemistry, 2008
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.
Pandit B et al.
Nature Genetics, 2007
Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.
Terai K et al.
Embo Reports, 2005
Raf-1 activation disrupts its binding to keratins during cell stress.
Ku NO et al.
The Journal of Cell Biology, 2004
Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites.
Hekman M et al.
The Journal of Biological Chemistry, 2004
Dephosphorylation of Ser-259 regulates Raf-1 membrane association.
Kubicek M et al.
The Journal of Biological Chemistry, 2002
Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association.
Yip-Schneider MT et al.
The Biochemical Journal, 2000
Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation.
MacNicol MC et al.
The Journal of Biological Chemistry, 2000
Sequential modification of serines 621 and 624 in the Raf-1 carboxyl terminus produces alterations in its electrophoretic mobility.
Ferrier AF et al.
The Journal of Biological Chemistry, 1997
The activity of D-raf in torso signal transduction is altered by serine substitution, N-terminal deletion, and membrane targeting.
Baek KH et al.
Developmental Biology, 1996
Mechanisms regulating Raf-1 activity in signal transduction pathways.
Morrison DK
Molecular Reproduction and Development, 1995
Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro.
Dent P et al.
Molecular and Cellular Biology, 1995
Identification of the major phosphorylation sites of the Raf-1 kinase.
Morrison DK et al.
The Journal of Biological Chemistry, 1993