Varaico: Literature-Extracted Genetic Variants

Gene:RAF1
Variant:p.D486A
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RAF1

NM_002880.4:p.D486A

Associated Papers

RAF1 kinase contributes to autophagic lysosome reformation.

Toifl S et al.

Cell Reports, 2025

RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status.

Dorard C et al.

Oncogene, 2023

Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation.

García-Alonso S et al.

Molecular Cell, 2022

An Update on the Biology of RAS/RAF Mutations in Colorectal Cancer.

Nandan MO et al.

Current Colorectal Cancer Reports, 2011

BRAF inactivation drives aneuploidy by deregulating CRAF.

Kamata T et al.

Cancer Research, 2010

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Hatzivassiliou G et al.

Nature, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."