Associated Papers
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis.
Wong S et al.
Embo Molecular Medicine, 2023
RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status.
Dorard C et al.
Oncogene, 2023
Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation.
Gao X et al.
Molecular Cell, 2022
Kinase-independent role for CRAF-driving tumour radioresistance via CHK2.
Advani SJ et al.
Nature Communications, 2015
Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf-DAPK Complex by Raf Inhibitor Combination Therapy.
Tsai YT et al.
Cancer Research, 2015
A MEK-independent role for CRAF in mitosis and tumor progression.
Mielgo A et al.
Nature Medicine, 2011
Spry2 does not directly modulate Raf-1 kinase activity in v-Ha-ras-transformed NIH 3T3 fibroblasts.
Ahn JH et al.
Bmb Reports, 2010
C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).
Karreth FA et al.
Molecular Cell, 2009
Characterization of Ser338 phosphorylation for Raf-1 activation.
Zang M et al.
The Journal of Biological Chemistry, 2008
CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation.
Ritt DA et al.
Current Biology : Cb, 2007
Regulation of RKIP binding to the N-region of the Raf-1 kinase.
Park S et al.
Febs Letters, 2006
Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein.
Brummer T et al.
Oncogene, 2006
Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.
von Kriegsheim A et al.
Nature Cell Biology, 2006
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Rodriguez-Viciana P et al.
Molecular Cell, 2006
Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.
Terai K et al.
Embo Reports, 2005
Raf-1 activation disrupts its binding to keratins during cell stress.
Ku NO et al.
The Journal of Cell Biology, 2004
Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism.
Chen C et al.
Blood, 2004
Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation.
Goetz CA et al.
The Journal of Biological Chemistry, 2003
Regulation of Raf through phosphorylation and N terminus-C terminus interaction.
Chong H et al.
The Journal of Biological Chemistry, 2003
The requirement of specific membrane domains for Raf-1 phosphorylation and activation.
Carey KD et al.
The Journal of Biological Chemistry, 2003
Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.
Xiang X et al.
The Journal of Biological Chemistry, 2002
Function of the Rho family GTPases in Ras-stimulated Raf activation.
Li W et al.
The Journal of Biological Chemistry, 2001
Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation.
Zang M et al.
The Journal of Biological Chemistry, 2001
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
Mason CS et al.
The Embo Journal, 1999
Characterization of Raf-1 activation in mitosis.
Laird AD et al.
The Journal of Biological Chemistry, 1999