Associated Papers
V(D)J Recombination: Recent Insights in Formation of the Recombinase Complex and Recruitment of DNA Repair Machinery.
Christie SM et al.
Frontiers in Cell and Developmental Biology, 2022
Full length RAG2 expression enhances the DNA damage response in pre-B cells.
Byrum JN et al.
Immunobiology, 2021
RAG2 localization and dynamics in the pre-B cell nucleus.
Rodgers W et al.
Plos One, 2019
The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect.
Hewitt SL et al.
Cell Reports, 2017
Physiological Roles of DNA Double-Strand Breaks.
Khan FA et al.
Journal of Nucleic Acids, 2017
The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.
Ochodnicka-Mackovicova K et al.
Journal of Immunology (baltimore, Md. : 1950), 2016
Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency.
Xu K et al.
European Journal of Immunology, 2016
Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus.
Mijušković M et al.
Cell Reports, 2015
Spatio-temporal regulation of RAG2 following genotoxic stress.
Rodgers W et al.
Dna Repair, 2015
RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ'.
Gigi V et al.
Nucleic Acids Research, 2014
RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.
Coussens MA et al.
Cell Reports, 2013
AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].
Ranjit S et al.
Journal of Immunology (baltimore, Md. : 1950), 2011
Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.
Zhang L et al.
Immunity, 2011
Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.
Ross AE et al.
Molecular and Cellular Biology, 2003
RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation.
Mizuta R et al.
The Journal of Biological Chemistry, 2002
A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle.
Li Z et al.
Immunity, 1996
Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation.
Lin WC et al.
Science (new York, N.y.), 1993
The roles of the RAG1 and RAG2 "non-core" regions in V(D)J recombination and lymphocyte development.
Jones JM et al.
Archivum Immunologiae Et Therapiae Experimentalis, 0