Associated Papers
The small GTPase Ran defines nuclear pore complex asymmetry.
Sachweh J et al.
Cell, 2025
The HIV-1 Nuclear Export Complex Reveals the Role of RNA in Crm1 Cargo Recognition.
Smith AM et al.
Biorxiv : the Preprint Server for Biology, 2024
B-type Plexins promote the GTPase activity of Ran to affect androgen receptor nuclear translocation in prostate cancer.
Garg R et al.
Cancer Gene Therapy, 2023
A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination.
Qiang L et al.
Nature Communications, 2023
AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer.
Kim S et al.
Elife, 2022
GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation.
Zhou J et al.
Molecular Biomedicine, 2020
C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import.
Hayes LR et al.
Elife, 2020
Insights into the assembly and activation of the microtubule nucleator γ-TuRC.
Liu P et al.
Nature, 2020
RASSF1A is required for the maintenance of nuclear actin levels.
Chatzifrangkeskou M et al.
The Embo Journal, 2019
The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.
Chen M et al.
The Journal of Cell Biology, 2017
The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation.
Xu Y et al.
Cell Discovery, 2016
MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia.
Dörr A et al.
The Journal of Biological Chemistry, 2015
Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly.
Vollmer B et al.
Developmental Cell, 2015
RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1.
Rajakylä EK et al.
Nature Communications, 2015
Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes.
Inoue A et al.
Nature Structural & Molecular Biology, 2014
Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.
Tsirkone VG et al.
Acta Crystallographica. Section F, Structural Biology Communications, 2014
Ran GTPase in nuclear envelope formation and cancer metastasis.
Matchett KB et al.
Advances in Experimental Medicine and Biology, 2014
Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation.
Milano SK et al.
The Journal of Biological Chemistry, 2012
Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.
Zhen Y et al.
Traffic (copenhagen, Denmark), 2012
Specific nuclear localizing sequence directs two myosin isoforms to the cell nucleus in calmodulin-sensitive manner.
Dzijak R et al.
Plos One, 2012
Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2.
Hurd TW et al.
Journal of Cell Science, 2011
Insights into the function of the CRM1 cofactor RanBP3 from the structure of its Ran-binding domain.
Langer K et al.
Plos One, 2011
Regulated degradation of spindle assembly factors by the anaphase-promoting complex.
Song L et al.
Molecular Cell, 2010
Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.
Dikovskaya D et al.
Journal of Cell Science, 2010
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.
Ly TK et al.
The Journal of Biological Chemistry, 2010
CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter.
Maquat LE et al.
Cold Spring Harbor Symposia on Quantitative Biology, 2010
Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta.
Sato H et al.
Genes & Development, 2009
The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly.
Joukov V et al.
Cell, 2006
The molecular motor KIFC1 associates with a complex containing nucleoporin NUP62 that is regulated during development and by the small GTPase RAN.
Yang WX et al.
Biology of Reproduction, 2006
Nuclear import and activity of histone deacetylase in Xenopus oocytes is regulated by phosphorylation.
Smillie DA et al.
Journal of Cell Science, 2004
Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta.
Cingolani G et al.
Molecular Cell, 2002
Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.
Moore W et al.
Current Biology : Cb, 2002
Role of importin-beta in the control of nuclear envelope assembly by Ran.
Zhang C et al.
Current Biology : Cb, 2002
In vitro analysis of nuclear transport mediated by the C-terminal shuttle domain of Tap.
Schmitt I et al.
The Journal of Biological Chemistry, 2001
The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2).
Stewart M et al.
Journal of Molecular Biology, 1998
The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants.
Hughes M et al.
Journal of Cell Science, 1998
Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import.
Percipalle P et al.
Journal of Molecular Biology, 1997
Mutations within the Ran/TC4 GTPase. Effects on regulatory factor interactions and subcellular localization.
Lounsbury KM et al.
The Journal of Biological Chemistry, 1996
Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.
Weis K et al.
The Embo Journal, 1996
RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.
Palacios I et al.
The Journal of Cell Biology, 1996
GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import.
Melchior F et al.
The Journal of Cell Biology, 1995
A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.
Dasso M et al.
The Embo Journal, 1994