Associated Papers
The PIN1-p38-CtIP signalling axis protects stalled replication forks from deleterious degradation.
Vivalda F et al.
Nucleic Acids Research, 2025
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.
Ceppi I et al.
Nature, 2024
Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy.
Zhou Q et al.
Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, 2024
ATM/ATR Phosphorylation of CtIP on Its Conserved Sae2-like Domain Is Required for Genotoxin-Induced DNA Resection but Dispensable for Animal Development.
Wu-Baer F et al.
Cells, 2023
Syk-dependent alternative homologous recombination activation promotes cancer resistance to DNA targeted therapy.
Zhou Q et al.
Research Square, 2023
ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen.
Najnin RA et al.
Cell Reports, 2023
CtIP-mediated alternative mRNA splicing fine-tunes the DNA damage response.
Prados-Carvajal R et al.
Rna (new York, N.y.), 2021
SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection.
Locke AJ et al.
Nucleic Acids Research, 2021
FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks.
Nath S et al.
Plos Genetics, 2020
CtIP is essential for early B cell proliferation and development in mice.
Liu X et al.
The Journal of Experimental Medicine, 2019
Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair.
Godau J et al.
Dna Repair, 2019
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress.
Przetocka S et al.
Molecular Cell, 2018
Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.
Cánovas B et al.
Cancer Cell, 2018
BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.
Sun C et al.
Cancer Cell, 2018
DNA end resection requires constitutive sumoylation of CtIP by CBX4.
Soria-Bretones I et al.
Nature Communications, 2017
Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection.
Anand R et al.
Molecular Cell, 2016
BRCA1, a 'complex' protein involved in the maintenance of genomic stability.
Savage KI et al.
The Febs Journal, 2015
APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage.
Lafranchi L et al.
The Embo Journal, 2014
Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
Barton O et al.
The Journal of Cell Biology, 2014
CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.
Wang H et al.
Molecular Cell, 2014
Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.
Makharashvili N et al.
Molecular Cell, 2014
CtIP-mediated resection is essential for viability and can operate independently of BRCA1.
Polato F et al.
The Journal of Experimental Medicine, 2014
FANCD2 and CtIP cooperate to repair DNA interstrand crosslinks.
Murina O et al.
Cell Reports, 2014
Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection.
Steger M et al.
Molecular Cell, 2013
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.
Escribano-Díaz C et al.
Molecular Cell, 2013
The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.
Wang H et al.
Plos Genetics, 2013
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.
Kousholt AN et al.
The Journal of Cell Biology, 2012
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.
You Z et al.
Trends in Cell Biology, 2010
Regulation of homologous recombination in eukaryotes.
Heyer WD et al.
Annual Review of Genetics, 2010
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.
Yun MH et al.
Nature, 2009
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair.
Huertas P et al.
The Journal of Biological Chemistry, 2009
CDK targets Sae2 to control DNA-end resection and homologous recombination.
Huertas P et al.
Nature, 2008