Varaico: Literature-Extracted Genetic Variants

Gene:RCC1
Variant:p.D182A
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RCC1

NM_001381865.2:p.D182A

Associated Papers

PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.

Huang T et al.

Molecular Cell, 2021

RCC1 regulates inner centromeric composition in a Ran-independent fashion.

Zhang MS et al.

Cell Cycle (georgetown, Tex.), 2018

Pivotal role of extended linker 2 in the activation of Gα by G protein-coupled receptor.

Huang J et al.

The Journal of Biological Chemistry, 2015

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.

Hitakomate E et al.

Bmc Cell Biology, 2010

Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1.

Hao Y et al.

The Journal of Cell Biology, 2008

RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation.

Hood FE et al.

Journal of Cell Science, 2007

N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis.

Chen T et al.

Nature Cell Biology, 2007

Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis.

Hutchins JR et al.

Current Biology : Cb, 2004

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.

Moore W et al.

Current Biology : Cb, 2002

Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1).

Renault L et al.

Cell, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."