Varaico: Literature-Extracted Genetic Variants

Gene:REG1A
Variant:p.D61Y
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REG1A

NM_002909.5:p.D61Y

Associated Papers

Transcriptome analysis reveals effects of leukemogenic SHP2 mutations in biosynthesis of amino acids signaling.

Zhao Y et al.

Frontiers in Oncology, 2023

Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2.

Solman M et al.

Frontiers in Cell and Developmental Biology, 2022

Exploring the reason for increased activity of SHP2 caused by D61Y mutation through molecular dynamics.

Wang RR et al.

Computational Biology and Chemistry, 2019

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.

Chen L et al.

Leukemia, 2015

The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease.

Lauriol J et al.

Seminars in Cell & Developmental Biology, 2015

Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations.

Yu ZH et al.

The Journal of Biological Chemistry, 2013

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.

Keilhack H et al.

The Journal of Biological Chemistry, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."