Varaico: Literature-Extracted Genetic Variants

Gene:RET
Variant:p.A4A
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RET

NM_020975.6:p.A4A

Associated Papers

Genomic Profile of Non-Small Cell Lung Cancer in a Spanish Cohort: A 2-Year Descriptive Study Using Next-Generation Sequencing.

Carnero-Gregorio M et al.

Genes, 2026

41751593 (PubMed )
Supplement: genes-17-00209-s001.zip › genes-4059941-SI.pdf

A Real-World Experience on the Efficacy of First-Line Treatment with Immune-Checkpoint Inhibitors in Non-Small-Cell Lung Cancer Patients with PD-L1 Expression ≥50%: The Role of KRAS Mutations.

Motta L et al.

Cancers, 2025

Aspyre Lung enables robust variant calling in samples that fail next generation sequencing quality control.

Gray ER et al.

Translational Oncology, 2025

41076960 (PubMed )
Supplement: mmc1.docx

Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer.

Sposito M et al.

Scientific Reports, 2025

41053251 (PubMed )
Supplement: 41598_2025_18662_MOESM1_ESM.docx

DNA damage response and repair gene mutations predict clinical outcomes in biliary tract cancer.

Tan S et al.

Cancer, 2025

39876053 (PubMed )
Supplement: supplement_1.pdf

The Role of miR-29a and miR-143 on the Anti-apoptotic MCL-1/cIAP-2 Genes Expression in EGFR Mutated Non-small Cell Lung Carcinoma Patients.

Abrehdari-Tafreshi Z et al.

Biochemical Genetics, 2024

Inflammatory Giant Cell Carcinoma of the Lung: Clinicopathologic, Immunohistochemical, and Next-generation Sequencing Study of 14 Cases.

Suster DI et al.

The American Journal of Surgical Pathology, 2024

Beyond tobacco: genomic disparities in lung cancer between smokers and never-smokers.

Garrido J et al.

Bmc Cancer, 2024

Japanese Society of Medical Oncology clinical guidelines: Molecular testing for colorectal cancer treatment, 5th edition.

Bando H et al.

Cancer Science, 2024

38263580 (PubMed )
Supplement: CAS-115-1014-s001.docx

Association of mutation profiles with metastasis in patients with non-small cell lung cancer.

Li Y et al.

Frontiers in Oncology, 2024

39464712 (PubMed )
Supplement: Table3.xlsx › LMG____

RET aberrant cancers and RET inhibitor therapies: Current state-of-the-art and future perspectives.

Addeo A et al.

Pharmacology & Therapeutics, 2023

Efficacy of Immunotherapy in Second-Line Treatment of KRAS-Mutated Patients with Non-Small-Cell Lung Cancer-Data from Daily Practice.

Knetki-Wróblewska M et al.

Current Oncology (toronto, Ont.), 2022

Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis.

Tabata J et al.

Cancer Research, 2022

Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer.

Church AJ et al.

Nature Medicine, 2022

Global prognostic impact of driver genetic alterations in patients with lung adenocarcinoma: a real-life study.

Paliogiannis P et al.

Bmc Pulmonary Medicine, 2022

Papillary renal neoplasm with reverse polarity: A clinicopathological and molecular genetic characterization of 16 cases with expanding the morphologic spectrum and further support for a novel entity.

Shen M et al.

Frontiers in Oncology, 2022

[Advances in Lung Cancer Treatment].

Schulz C

Deutsche Medizinische Wochenschrift (1946), 2021

Oncogene-specific differences in tumor mutational burden, PD-L1 expression, and outcomes from immunotherapy in non-small cell lung cancer.

Negrao MV et al.

Journal for Immunotherapy of Cancer, 2021

34376553 (PubMed )
Supplement: jitc-2021-002891supp001.pdf

Outcomes and prognostic contributors in patients with KRAS mutated non-small cell pulmonary adenocarcinomas: a single institution experience.

Burns EA et al.

Journal of Thoracic Disease, 2021

Profiling Oncogenic Germline Mutations in Unselected Chinese Lung Cancer Patients.

Yang J et al.

Frontiers in Oncology, 2021

Epidemiologic Features of NSCLC Gene Alterations in Hispanic Patients from Puerto Rico.

Zheng R et al.

Cancers, 2020

Long-read sequencing for non-small-cell lung cancer genomes.

Sakamoto Y et al.

Genome Research, 2020

32887687 (PubMed )
Supplement: supp_gr.261941.120_Supplemental_material.docx

Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups.

Egan C et al.

Haematologica, 2020

The correlations of tumor mutational burden among single-region tissue, multi-region tissues and blood in non-small cell lung cancer.

Zhang Y et al.

Journal for Immunotherapy of Cancer, 2019

30944026 (PubMed )
Supplement: 40425_2019_581_MOESM3_ESM.pdf

Analysis of the frequency of oncogenic driver mutations and correlation with clinicopathological characteristics in patients with lung adenocarcinoma from Northeastern Switzerland.

Grosse A et al.

Diagnostic Pathology, 2019

Detection of RAS and RAS-associated alterations in primary lung adenocarcinomas. A correlation between molecular findings and tumor characteristics.

Shaukat I et al.

Human Pathology, 2019

Targeted Sequencing Analysis of Pulmonary Adenocarcinoma with Multiple Synchronous Ground-Glass/Lepidic Nodules.

Park E et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2018

A KRAS wild type mutational status confers a survival advantage in pancreatic ductal adenocarcinoma.

Windon AL et al.

Journal of Gastrointestinal Oncology, 2018

RET Aberrations in Diverse Cancers: Next-Generation Sequencing of 4,871 Patients.

Kato S et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

27683183 (PubMed )
Supplement: 10780432ccr161679-sup-168576_1_supp_3636667_wcc1ns.docx

Concurrent oncogene mutation profile in Chinese patients with stage Ib lung adenocarcinoma.

Wen YS et al.

Medicine, 2014

A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma.

Ross JS et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2014

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Morris EJ et al.

Cancer Discovery, 2013

23614898 (PubMed )
Supplement: 21598290cd130070-sup-supplementary_figures_-_pdf_file_1385k.pdf

Characteristics of lung cancers harboring NRAS mutations.

Ohashi K et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2013

Keratinocytic epidermal nevi are associated with mosaic RAS mutations.

Hafner C et al.

Journal of Medical Genetics, 2012

KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.

Tie J et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

21239505 (PubMed )
Supplement: 10780432ccr101720-sup-supplementary_tables_s1-s4.pdf

High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer.

Simi L et al.

American Journal of Clinical Pathology, 2008

Molecular Signatures of KRAS-Mutated Lung Adenocarcinoma: Analysis of Concomitant EGFR, ALK, STK11, and PD-L1 Status.

Hsu J et al.

Clinical Pathology (thousand Oaks, Ventura County, Calif.), 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."