Associated Papers
CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
Qiu T et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.
Cuesta-Hernández HN et al.
Nature Communications, 2023
TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation.
Guo Q et al.
Cell Reports, 2023
Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability.
Shehata MA et al.
Journal of Advanced Research, 2023
Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis.
Tabata J et al.
Cancer Research, 2022
A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions.
Estrada-Zuniga CM et al.
Cell Reports. Medicine, 2022
RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma.
Moodley S et al.
Lung Cancer (amsterdam, Netherlands), 2020
GGA3-mediated recycling of the RET receptor tyrosine kinase contributes to cell migration and invasion.
Crupi MJF et al.
Oncogene, 2020
A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis.
Azad T et al.
Oncogene, 2020
ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma.
Luo J et al.
Theranostics, 2019
RET rearrangements are actionable alterations in breast cancer.
Paratala BS et al.
Nature Communications, 2018
Structure and function of RET in multiple endocrine neoplasia type 2.
Plaza-Menacho I
Endocrine-related Cancer, 2018
Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480.
Gudernova I et al.
Oncotarget, 2017
Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization.
Hyndman BD et al.
Journal of Cell Science, 2017
Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors.
Wills MK et al.
The Journal of Biological Chemistry, 2017
RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.
Plaza-Menacho I et al.
Cell Reports, 2016
Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2.
Crupi MJ et al.
Traffic (copenhagen, Denmark), 2015
A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis.
Bagheri-Yarmand R et al.
The Journal of Biological Chemistry, 2015
Mechanisms of RET signaling in cancer: current and future implications for targeted therapy.
Plaza-Menacho I et al.
Cellular Signalling, 2014
Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Plaza-Menacho I et al.
Molecular Cell, 2014
Multiple functional effects of RET kinase domain sequence variants in Hirschsprung disease.
Hyndman BD et al.
Human Mutation, 2013
Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations.
Chatterjee R et al.
Human Genetics, 2012
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.
Plaza-Menacho I et al.
The Journal of Biological Chemistry, 2011
Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase.
Perrinjaquet M et al.
The Journal of Biological Chemistry, 2010
Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins.
Richardson DS et al.
Cancer Research, 2009
XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway.
Lodyga M et al.
Oncogene, 2009
RET Gly691Ser mutation is associated with primary vesicoureteral reflux in the French-Canadian population from Quebec.
Yang Y et al.
Human Mutation, 2008
A novel RET kinase-beta-catenin signaling pathway contributes to tumorigenesis in thyroid carcinoma.
Gujral TS et al.
Cancer Research, 2008
Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B.
Gujral TS et al.
Cancer Research, 2006
RET ligand-induced internalization and its consequences for downstream signaling.
Richardson DS et al.
Oncogene, 2006
Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth.
Zhang Y et al.
Journal of Cell Science, 2006
Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase.
Scott RP et al.
The Journal of Biological Chemistry, 2005
Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis.
Jain S et al.
Development (cambridge, England), 2004
Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.
Crowder RJ et al.
The Journal of Biological Chemistry, 2004
Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival.
Encinas M et al.
The Journal of Biological Chemistry, 2004
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells.
Castellone MD et al.
Oncogene, 2004
RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1.
Kim DW et al.
Molecular Endocrinology (baltimore, Md.), 2003
Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes.
Castellone MD et al.
Oncogene, 2003
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.
Grimm J et al.
The Journal of Cell Biology, 2001