Associated Papers
RET Gene Alterations in Clinical Practice: A Comprehensive Review and Database Update.
Ricciardi Tenore C et al.
Genes, 2025
Somatic mutations in Middle East and North Africa breast cancer patients: a systematic review.
Abujamous L et al.
The Oncologist, 2025
A Single RET Mutation in Hirschsprung Disease Induces Intestinal Aganglionosis Via a Dominant-Negative Mechanism.
Sunardi M et al.
Cellular and Molecular Gastroenterology and Hepatology, 2023
Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis.
Tabata J et al.
Cancer Research, 2022
Targeted Next-Generation Sequencing-Based Multiple Gene Mutation Profiling of Patients with Rectal Adenocarcinoma Receiving or Not Receiving Neoadjuvant Chemoradiotherapy.
Chang YK et al.
International Journal of Molecular Sciences, 2022
The RET gene encodes RET protein, which triggers intracellular signaling pathways for enteric neurogenesis, and RET mutation results in Hirschsprung's disease.
Bhattarai C et al.
Aims Neuroscience, 2022
Comprehensive Assessment of Indian Variations in the Druggable Kinome Landscape Highlights Distinct Insights at the Sequence, Structure and Pharmacogenomic Stratum.
Panda G et al.
Frontiers in Pharmacology, 2022
Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development.
Kuil LE et al.
Plos Genetics, 2021
Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients.
Barakeh DH et al.
Oncotarget, 2021
Sequence characterization of RET in 117 Chinese Hirschsprung disease families identifies a large burden of de novo and parental mosaic mutations.
Jiang Q et al.
Orphanet Journal of Rare Diseases, 2019
Targeted next-generation sequencing of well-differentiated rectal, gastric, and appendiceal neuroendocrine tumors to identify potential targets.
Park HY et al.
Human Pathology, 2019
Structure and function of RET in multiple endocrine neoplasia type 2.
Plaza-Menacho I
Endocrine-related Cancer, 2018
In silico profiling and structural insights of missense mutations in RET protein kinase domain by molecular dynamics and docking approach.
George Priya Doss C et al.
Molecular Biosystems, 2014
Multiple functional effects of RET kinase domain sequence variants in Hirschsprung disease.
Hyndman BD et al.
Human Mutation, 2013
[Molecular biology, basic research and diagnosis of Hirschsprung's disease].
Martucciello G et al.
Der Pathologe, 2007
Structure and chemical inhibition of the RET tyrosine kinase domain.
Knowles PP et al.
The Journal of Biological Chemistry, 2006
RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease.
Asai N et al.
Pathology International, 2006
Haplotypes of the human RET proto-oncogene associated with Hirschsprung disease in the Italian population derive from a single ancestral combination of alleles.
Lantieri F et al.
Annals of Human Genetics, 2006
Single nucleotide polymorphic alleles in the 5' region of the RET proto-oncogene define a risk haplotype in Hirschsprung's disease.
Sancandi M et al.
Journal of Medical Genetics, 2003
Association between c135G/A genotype and RET proto-oncogene germline mutations and phenotype of Hirschsprung's disease.
Fitze G et al.
Lancet (london, England), 2002
Functional analysis of RET with Hirschsprung mutations affecting its kinase domain.
Iwashita T et al.
Gastroenterology, 2001
Large and diverse numbers of human diseases with HIKE mutations.
Ciccarelli FD et al.
Human Molecular Genetics, 2000
Hirschsprung's disease as a neurochristopathy.
Martucciello G
Pediatric Surgery International, 1997
Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and hirschsprung disease.
Eng C et al.
Human Mutation, 1997
Frequency of RET mutations in long- and short-segment Hirschsprung disease.
Seri M et al.
Human Mutation, 1997
RET mutations in multiple endocrine neoplasia type 2 and Hirschsprung disease.
Reynolds LF et al.
Current Opinion in Pediatrics, 1995
Loss of function effect of RET mutations causing Hirschsprung disease.
Pasini B et al.
Nature Genetics, 1995