Varaico: Literature-Extracted Genetic Variants

Gene:RET
Variant:p.Y900F
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RET

NM_020975.6:p.Y900F

Associated Papers

Molecular dynamics study of enhanced autophosphorylation by S904F mutation of the RET kinase domain.

Chen YJ et al.

Journal of Structural Biology, 2021

Intracellular RET signaling pathways activated by GDNF.

Kawai K et al.

Cell and Tissue Research, 2020

RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.

Plaza-Menacho I et al.

Cell Reports, 2016

Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.

Plaza-Menacho I et al.

Molecular Cell, 2014

Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.

Plaza-Menacho I et al.

The Journal of Biological Chemistry, 2011

Expression, purification, and inhibition of human RET tyrosine kinase.

Mologni L et al.

Protein Expression and Purification, 2005

Identification of RET autophosphorylation sites by mass spectrometry.

Kawamoto Y et al.

The Journal of Biological Chemistry, 2004

Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.

Kato M et al.

Cancer Research, 2002

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."