Associated Papers
CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
Qiu T et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
OLFM4-RET fusion is an oncogenic driver in small intestine adenocarcinoma.
Liu W et al.
Oncogene, 2022
Molecular dynamics study of enhanced autophosphorylation by S904F mutation of the RET kinase domain.
Chen YJ et al.
Journal of Structural Biology, 2021
Intracellular RET signaling pathways activated by GDNF.
Kawai K et al.
Cell and Tissue Research, 2020
RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.
Plaza-Menacho I et al.
Cell Reports, 2016
Exon Skipping in the RET Gene Encodes Novel Isoforms That Differentially Regulate RET Protein Signal Transduction.
Gabreski NA et al.
The Journal of Biological Chemistry, 2016
Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking.
Zhu S et al.
Nature Neuroscience, 2015
Mechanisms of RET signaling in cancer: current and future implications for targeted therapy.
Plaza-Menacho I et al.
Cellular Signalling, 2014
Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Plaza-Menacho I et al.
Molecular Cell, 2014
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.
Plaza-Menacho I et al.
The Journal of Biological Chemistry, 2011
SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling.
Donatello S et al.
Oncogene, 2007
Structure and chemical inhibition of the RET tyrosine kinase domain.
Knowles PP et al.
The Journal of Biological Chemistry, 2006
Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth.
Zhang Y et al.
Journal of Cell Science, 2006
Expression, purification, and inhibition of human RET tyrosine kinase.
Mologni L et al.
Protein Expression and Purification, 2005
Identification of RET autophosphorylation sites by mass spectrometry.
Kawamoto Y et al.
The Journal of Biological Chemistry, 2004
The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation.
Buckwalter TL et al.
Oncogene, 2002
Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.
Kato M et al.
Cancer Research, 2002
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.
Melillo RM et al.
Molecular and Cellular Biology, 2001
Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.
Kurokawa K et al.
Oncogene, 2001
Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts.
Paratcha G et al.
Neuron, 2001
Cancers connected with mutations in RET proto-oncogene.
Altanerová V
Neoplasma, 2001
Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.
Besset V et al.
The Journal of Biological Chemistry, 2000
Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins.
Salvatore D et al.
The Journal of Clinical Endocrinology and Metabolism, 2000
Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma.
Iwashita T et al.
Oncogene, 1999
Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.
Iwashita T et al.
Oncogene, 1996
Detection of the PTC/retTPC oncogene in human thyroid cancers.
Jhiang SM et al.
Oncogene, 1992